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IP Roundup: Jan 11, 2011


Postech Foundation of Pohang, Korea, has received US Patent No. 7,867,391, "Cucurbituril derivative-bonded solid substrate and biochip using the same." The patent provides a cucurbituril derivative-bonded solid substrate, a protein chip using the cucurbituril derivative-bonded solid substrate, a gene chip using the cucurbituril derivative-bonded solid substrate, and a sensor for a biomaterial assay using the cucurbituril derivative-bonded solid substrate.

Dako of Glostrup, Denmark, has received US Patent No. 7,867,443, "Method and apparatus for automated pre-treatment and processing of biological samples." The patent claims a method for automatic staining of a biological sample on a slide. The method includes applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol. A method of antigen retrieval is also provided that includes contacting, within a heated processing tank of an automated staining apparatus, a biological sample with compositions for antigen retrieval.

Fluidigm of South San Francisco, Calif., has received US Patent No. 7,867,454, "Thermal reaction device and method for using the same." The patent claims a microfluidic device for performing a matrix of reactions, where the device has reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.

Fluidigm has also received US Patent No. 7,867,763, "Integrated chip carriers with thermocycler interfaces and methods of using the same." Methods are provided for conducting a reaction at a selected temperature or range of temperatures over time in an array device. According to the patent, the array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. A thermal transfer device is next to the reaction chambers, and the thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device, and the array device is contacted with a thermal control device so that the temperature is changed.

Corning of Corning, NY, has received US Patent No. 7,867,700, "Porous substrate plates and the use thereof." The patent claims a substrate plate or device adapted for use with biological or chemical assays. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized as having interconnected voids defined by a matrix of contiguous solid material.

Agilent Technologies has received US Patent No. 7,867,703, "Element defined sequence complexity reduction." The patent claims a method for providing defined mixtures of nucleic acids. The method uses oligonucleotide probes attached to a solid support as a sequence-specific affinity agent to isolate and facilitate the amplification of defined nucleic acid fragment mixtures.

Evotec of Hamburg, Germany, has received US Patent No. 7,867,707, "Method for detecting analytes in a sample." The patent claims a method for detecting analytes in a sample by: a) providing a solid support and providing capture probes being bound or capable of binding to the solid support, where capture probes are also capable of binding to the analytes; b) providing detection probes that are capable of binding to the analytes; c) contacting the sample with the detection probes, the solid support and the capture probes; and d) detecting through the use of confocal observation the analytes that are bound to the detection probes.

Purdue Research Foundation of West Lafayette, Ind., has received US Patent No. 7,867,754, "Microarrays for analyte detection." The patent claims a method for the detection of analytes, particularly biohazards. According to the patent, a microarray containing immobilized sensing molecules captures complementary analytes on a redundant patterned substrate. Pattern analysis is subsequently performed using a computer algorithm.

Maven Technologies of Los Angeles has received US Patent No. 7,867,783, "Apparatus and method for performing ligand binding assays on microarrays in multiwell plates." The patent claims a method for real-time, label-free imaging and quantitation of binding events at an array of positions. Total internal reflection from a planar side wall of a well of a multiwell plate is used to create an evanescent field in the plane of a pattern of ligands immobilized on the wall, according to the patent.

North Carolina State University has received US Patent No. 7,868,161, "Photocrosslinking probes and uses of the same." The patent claims a method of detecting a target nucleic acid by detecting the presence of a fluorescent covalent crosslinked product from non-fluorescent precursors. According to the patent, the fluorescent covalent crosslinked product is a fluorophore structure. Methods of synthesizing probe molecules that can form fluorescent covalent crosslinked products with nucleic acid targets, such as arrays, are also claimed.

Roche NimbleGen has received US Patent No. 7,869,959, "Optimized probe selection method." The patent provides a method for optimizing oligonucleotide probes for use in a hybridization-based assay. The method includes the steps of: a) providing oligo probes on a hybridization array; b) providing serial dilutions of a genomic sample, where the genomic sample is labeled; c) hybridizing the labeled and serially diluted genomic sample to the probes on the array, so that a signal intensity is produced for each of the probes, wherein the hybridization step is performed at least one time; d) computationally generating weighted regression data from the signal intensity produced for each of the probes; and e) identifying optimized probes from the plurality of oligonucleotide probes on the hybridization array for use in the assay using a probe-selection algorithm reliant upon the weighted regression data, where the optimized probes exhibit signal intensities proportional to the serial dilutions of the genomic sample and having maximal brightness at each serial dilution.

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