Agilent Technologies has received US Patent No. 7,807,354, "Low volume hybridization." The patent claims a method of commingling a low volume of a target solution with an array. The method includes introducing a quantity of the target solution dissolved in an aqueous phase and a quantity of an immiscible liquid into a cavity that has an array on an interior surface. The method is carried out so that the quantities of target solution and immiscible liquid do not fill the volume and so that a gas is contained within the volume.