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IP Roundup: Mar 31, 2009


Illumina has received US Patent No. 7,510,841, "Methods of making and using composite arrays for the detection of a plurality of target analytes." The patent describes a method of detecting the presence or absence of different target analytes by: a) providing a first substrate with a surface comprising a plurality of assay wells, where the assay wells contain sample solutions with different target analytes; b) providing a second substrate with a plurality of array locations, where the sites comprise different bioactive agents; c) dipping the projections of the second substrate into the assay wells so that each array location on the second substrate contacts the sample solution in a different well of the first substrate under conditions suitable for binding of different target analytes to different bioactive agents; and d) detecting the presence or absence of target analytes.

Samsung Electronics of Seoul, Korea, has received US Patent No. 7,510,865, "Sensing switch and detecting method using the same." The patent claims a sensing switch and a sensing method using the same. The sensing switch includes: a) a substrate; b) a supporter on the substrate; c) a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; d) a receptor-binding region on an upper surface of an end portion of the sensing plate; e) an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and f) a pair of switching electrodes that are separated by a predetermined distance and are connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. According to the patent, a signal can be directly decoded by confirming whether a current flows through the switch.

Cargill of Wayzata, Minn., and MetaMorphix of Beltsville, Md., have received US Patent No. 7,511,127, "Compositions, methods and systems for inferring bovine breed." The patent claims methods to discover and use single nucleotide polymorphisms for identifying breed, or line and breed, or line composition of a bovine subject. The patent provides specific nucleic acid sequences, SNPs, and SNP patterns that can be used for identifying breed or breed combinations for Angus, Holstein, Limousin, Brahman, Hereford, Simmental, Gelbvieh, Charolais, and Beefmaster breeds. These patterns can be utilized to manage animals in a feedlot to obtain optimum performance based on known characteristics of specific breeds and identify animals for breeding in selection programs. In another aspect, these patterns can also be used to ensure labeling on breed specific branded products.

Baylor College of Medicine and Rice University, both of Houston have received US Patent No. 7,511,811, "Pulsed-multiline excitation for color-blind fluorescence detection." The patent claims a technology called pulse-multiline excitation, described as an approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. According to the patent, PME technology enables optimal excitation of all fluorophores in a genomic assay and "color-blind" detection, which collects more light than standard wavelength resolved detection.

Soheil Shams of Redondo Beach, Calif., and Anton Petrov of Los Angeles have received US Patent No. 7,512,496, "Apparatus, method, and computer program product for determining confidence measures and combined confidence measures for assessing the quality of microarrays." The patent claims an apparatus, method, and computer program product for determining a confidence measure for the output of a process for assessing proteomic and genomic information samples. Typically, the data in question is received as the results from a microarray experiment. The confidence measure is intended to determine whether the results of the experiment have been degraded due to experimental error. Several criteria are used by which quality is determined. The criteria are preferably combined into a combined quality measure in order to account for several possible sources of error.

The Scan

White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds

A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.

Study Points to Benefits of Local Consolidative Therapy, Targeted Treatments in Cancer Care

In JCO Precision Oncology, researchers report that local consolidative therapy combined with molecularly targeted treatments could improve survival for some lung cancer patients.

Genetic Variants That Lower LDL Cholesterol Linked to Reduced Heart Disease Risk

Rare variants in two genes that lower LDL cholesterol are also associated with a decreased risk of coronary heart disease, according to a new JAMA Cardiology study.

Study Links Evolution of Longevity, Social Organization in Mammals

With the help of comparative phylogenetics and transcriptomics, researchers in Nature Communications see ties between lifespan and social organization in mammals.