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IP Roundup: Aug 25, 2010

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Samsung Electronics has received US Patent No. 7,781,167, "Molecular detection methods using molecular detection chips including a metal oxide semiconductor field effect transistor." The patent claims a molecular detection chip that includes a metal oxide silicon-field effect transistor on the sidewalls of a micro-fluid channel and a molecular detection device. A molecular detection method that includes qualification methods for the immobilization of molecular probes and the binding of a target sample to the molecular probes, using the molecular detection device, and a nucleic acid mutation assay device and method are also provided.


Corning of Corning, NY, has received US Patent No. 7,781,203, "Supports for assaying analytes and methods of making and using thereof." The patent claims a substrate for performing an assay. The claimed substrate has a pre-blocked binding polymer attached, where the pre-blocked binding polymer contains maleic anhydride reactive groups capable of attaching to a biomolecule, as well as ionizable groups. The pre-blocked binding polymer does not contain a photoreactive group.


Yokogawa Electric of Tokyo has received US Patent No. 7,781,204, "Method for analyzing a biochip." The patent claims a biochip containing a number of fluorescent molecules. According to the patent, the sites of the bound molecules are known and respective hybridization efficiencies at the probe sites can be quantitatively grasped by comparing respective intensity of fluorescent light of the probe sites with an intensity of fluorescent light of the marker sites.


The University of Texas of Austin has received US Patent No. 7,781,226, "Particle on membrane assay system." The patent claims a portable analyte-detection instrument suitable for point-of-care analyses. According to the patent, the instrument includes a disposable cartridge, an optical detector, a sample collection device and sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and waste reservoirs. The device is capable of obtaining diagnostic information using cellular- and particle-based analyses and may be used with membrane- and particle-based analysis cartridges, the patent states. Analytes, including proteins and cells and microbes may be detected using the membrane- and particle-based analysis system.


Cornell Research Foundation of Ithaca, NY, has received US Patent No. 7,781,378, "Protective coating for array material deposition." The patent claims a method for forming an array with a protective cover on a substrate. The protective cover is patterned to produce an array of openings to the substrate, and desired material is deposited on the substrate through the openings, the patent states. According to the patent, the protective cover may be a conformal polymer, and the material may be biological material such as DNA. The protective cover may be used to prevent non-specific hybridization in inter-spot regions by performing hybridization with the cover still in place, the patent states. Hybridization that occurs in such regions between the spots may then be removed with removal of the protective cover.

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.