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IP Roundup: Aug 17, 2010


Autogenomics of Carlsbad, Calif., has received US Patent No. 7,776,195, "Integrated sample processing platform." The patent claims a desktop analytic device. The device includes a horizontal sample processing platform that is configured to receive a biochip, where the biochip is partially enclosed in a housing, and where the housing is configured to allow partial immersion of the biochip by a fluid that is retained by the housing. The device also contains an energy source that is thermally and mechanically coupled to the platform and is configured to allow the delivery of energy from the platform through the housing to the fluid in the biochip, while the biochip is disposed on the platform; a confocal microscope detector coupled to the platform so that a horizontal transport path is formed between the detector and the platform; a push actuator operationally coupled to a robotic arm, where the robotic arm and the push actuator are configured to allow pushing of the biochip along a y-coordinate in a sliding motion from the platform into the detector via the transport path; and a magazine that is configured to hold a plurality of biochips. According to the patent, the robotic arm, the platform, and the detector are configured so that the biochip is movable by the actuator in a sliding motion within the desktop analytic device without manual intervention of an operator from the magazine to the platform, and from the platform to the detector while an analyte is bound to the biochip.

Illumina has received US Patent No. 7,776,531, "Compositions and methods for stabilizing surface bound probes." The patent provides a method for detecting a target analyte by providing a substrate comprising an attached polynucleotide, where the substrate also includes a stabilization polymer layer; storing the substrate for a period of at least 24 hours; removing the stabilization polymer layer from the substrate; contacting the substrate with a target analyte, where the target analyte specifically binds to the attached polynucleotide; and detecting the presence of the target analyte.

The State University of New York of Albany has received US Patent No. 7,776,794, "Biosensor using living cells on silicon-based microarrays." The patent claims a biosensor composed of living cells that express a chemosensor, or receptor, on their surface. When grown on an electrode microarray, the cells can be induced, by binding of a ligand to the receptor, to secrete a molecule. This secretion event is detected with millisecond temporal resolution via electrochemical oxidation of the secreted molecule on the electrode, which is voltage-clamped slightly above its redox potential, according to the patent. The current so generated is indicative of the amount of the ligand bound to the receptor.

Rosetta Genomics of Rehovot, Israel, has received US Patent No. 7,777,022, "Bioinformatically detectable group of novel regulatory viral and viral associated oligonucleotides and uses thereof." The patent describes a first group of viral and human associated oligonucleotides, identified as genomic address messenger, or GAM, oligonucleotides, and a second group of operon-like viral and human polynucleotides, identified as genomic record, or GR, polynucleotides. GAM oligonucleotides selectively inhibit translation of known target genes, many of which are known to be involved in various viral diseases, according to the patent. Nucleic acid molecules are also provided respectively encoding 1,655 viral and 105,537 human GAM precursor oligonucleotides, and 190 viral and 14,813 human GR polynucleotides, as are vectors and probes comprising the nucleic acid molecules. Methods and systems for detecting GAM oligonucleotides and GR polynucleotides and their specific functions, including by using microarrays, are also claimed.

Aviva Biosciences of San Diego and Tsinghua University and CapitalBio, both of Beijing, have received US Patent No. 7,776,543, "Microdevice containing photorecognizable coding patterns and methods of using and producing the same." This patent provides a microdevice, which includes: a substrate; and a photorecognizable coding pattern on the substrate. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The patent also claims two-dimensional optical encoders and means for using them.

The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.