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IP Roundup: Aug 10, 2010


IMEC, of Leuven, Belgium, has received US Patent No. 7,770,437, "Thiol or disulfide molecules having poly(ethylene oxide) groups for use in a self-assembled monolayer bound to a metal layer for covalently immobilizing biomolecules in a biosensor." The patent claims a method of immobilizing functional organic biomolecules through a covalent bond to a thiolate or disulfide monolayer to a metal surface. Additionally, a sensor device that includes these monolayers is also provided to perform bioanalysis.

NuGen Technologies of San Carlos, Calif., has received US Patent No. 7,771,934, "Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof." The patent claims isothermal methods of generating multiple copies of, detecting, and quantifying nucleic acid sequences of interest based on limited primer extension or attachment of oligonucleotide pairs using composite RNA/DNA primers. Methods for generating multiple copies of nucleic acid sequences, where cleavage of the products results in dissociation of cleaved products from target polynucleotides, are also provided.

NuGen has also received US Patent No. 7,771,946, "Methods, kits and compositions for single primer linear isothermal amplification of nucleic acid sequences." The patent provides methods for isothermal amplification of RNA. The methods employ a composite primer, a second primer, and strand displacement to generate multiple copies of DNA products comprising sequences complementary to an RNA sequence of interest. The methods are useful for preparation of nucleic acid libraries and substrates for analysis of gene expression of cells in biological samples, according to the patent.

Marligen Biosciences of Ijamsville, Md., has received US Patent No. 7,771,940, "Methods of detecting a plurality of sequence specific DNA binding proteins with oligonucleotide detection duplexes." The patent claims methods for detecting and measuring DNA-binding proteins. The methods permit the detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors, according to the patent. Multiple protein-DNA binding events in a single sample may be also detected and quantitated in a high-throughput format.

The University of Maryland of College Park has received US Patent No. 7,771,955, "Affinity membrane for capture of a target biomolecule and formation thereof by site-directed immobilization of a capture biomolecule." The patent claims a method for orienting an immobilized capture biomolecule on a hydrophobic membrane. The method includes layering at least one tie layer on a hydrophobic membrane, adding an amine functional layer on top of at least one tie layer; and attaching an alignment biomolecule to the amine functional layer. According to the patent, the alignment biomolecule has the ability to either capture a target biomolecule itself and be considered a capture biomolecule, or bind and orient the immobilized capture biomolecule to maximize the binding activity of the immobilized capture biomolecule.

Biotray of Lyon, France, has received US Patent No. 7,772,010, "Mixing and dispensing homogeneous compounds of a reactant on a surface." The patent claims a method for mixing and dispensing compounds, including one reactant, in a carrier fluid in laminar flow, and a cell for implementing the method. The method and cell can be used to prepare homogeneous surface films, or to carry out target-probe identification reactions, according to the patent.

Nanosphere of Northbrook, Ill., has received US Patent No. 7,773,790, "Method for detecting the presence of a target analyte in a test spot." The patent describes an apparatus for imaging metallic nanoparticles. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module, an illumination module, a power module, an input module, and an output module. The apparatus may also include a stationary substrate holder and imaging module which are proximate to one another. A method for the automatic detection of spots or wells on the substrate, automatic quantification of the spots on the substrate, and automatic interpretation of the spots based on decision statistics, is also claimed.

The Scan

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A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.