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Quest Diagnostics of Wilmington, Del., has received US Patent No. 7,507,539, "Substractive single label comparative hybridization." The patent claims methods of determining the differences between nucleic acids in a test sample and a reference sample. In certain embodiments, the methods are used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants, the patent states.

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