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Affymetrix has received US Patent No. 7,745,178, "Complexity management of genomic DNA." The patent describes non-gel-based methods for amplifying a subset of the sequences in a sample in order to reduce nucleic acid sample complexity. This amplification can be accomplished by digesting a sample with two or more restriction enzymes and ligating adaptors to the fragments so that only a subset of the fragments can be amplified, according to the patent.

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