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IP Roundup: Apr 13, 2010

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Fluidigm of South San Francisco, Calif., has received US Patent No. 7,695,683, "Method and system for microfluidic device and imaging thereof." The patent describes a method of manufacturing a substrate. The substrate includes a rigid material that has a surface region capable of acting as a handle substrate, according to the patent. The substrate also has a deformable fluid layer coupled to the surface region. One or more well regions are formed in a first portion of the deformable fluid layer and are capable of holding a fluid. The channel regions are formed in a second portion of the deformable fluid layer and are coupled to one or more of the well regions. An active region is formed in the deformable fluid layer. At least three fiducial markings are formed within the non-active region and disposed in a spatial manner associated with at least one of the well regions. A control layer is also coupled to the fluid layer.


The National Institute for Materials Science of Ibaraki, Japan, has received US Patent No. 7,695,907, "Gene detection field-effect device and method of analyzing gene polymorphism therewith." According to the patent, the claimed gene detection field-effect device contains an insulation film, including a nucleic acid probe immobilized on its surface in contact with a sample solution that contains a target gene for detection and analysis. The semiconductor substrate abuts the other surface of the insulation film, and the reference electrode is provided in the sample solution.


Samsung Electronics has received US Patent No. 7,695,910, "Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group." The patent claims a biochip-manufacturing method, where a star-like polyethylene glycol derivative having an epoxy group at its terminal is reacted with a low molecular weight hydrophilic polymer to form a matrix, and a probe is covalently bound to the matrix and immobilized on a solid substrate. The biochip has a three-dimensional structure where it spatially protrudes from its surface and improves chip sensitivity, according to the patent. In addition, the biochip can be manufactured using an aqueous solution at low cost.


Plexera Bioscience of Bothell, Wash., has received US Patent No. 7,695,976, "Method for uniform analyte fluid delivery to microarrays." The patent claims a method of chemical analysis that includes: a) introducing an analyte fluid to a surface of a sample chip through a microfluidic device, where the device includes a fluid inlet having a semi-circular groove; b) maintaining the flow of the analyte fluid so that the analyte fluid forms a pattern on the surface of the sample chip, the pattern approximating the semi-circular groove; c) maintaining the flow of the analyte fluid so that a linear fluid front forms on the surface of the sample chip at the inlet end; and d) maintaining the flow so that the linear fluid front moves along the surface of the sample chip.


LG Life Sciences of Seoul, Korea, has received US Patent No. 7,696,130, "PNA chip using plastic substrate coated with epoxy group-containing polymer, method of manufacturing the PNA chip, and method of detecting single nucleotide polymorphism using the PNA chip." The patent claims a peptide nucleic acid, or PNA, chip, where PNA probes containing desired DNA sequences are immobilized on a plastic substrate coated with an epoxy group-containing polymer. Single-stranded PNAs can be immobilized on the transparent plastic substrate in a cost-effective manner, according to the patent. Additionally, fluorescence signal detection based on PNA/DNA hybridization enables the identification of SNPs.


Roche has received US Patent No. 7,698,117, "System and method for predicting chromosomal regions that control phenotypic traits." The patent claims a method of associating a phenotype with one or more candidate chromosomal regions in a genome of an organism. The method includes the step of deriving a phenotypic data structure that represents differences in phenotypes between different strains of the organism. According to the patent, a genotypic data structure is established that corresponds to a locus selected from loci in the genome of the organism. The phenotypic data structure is compared to the genotypic data structure to form a correlation value. The process of establishing a genotypic data structure and comparing it to the phenotypic data structure is repeated for each locus, resulting in the identification of genotypic data structures that form a high correlation value relative to all other compared genotypic data structures. The loci that correspond to the one or more genotypic data structures having a high correlation value represent the one or more candidate chromosomal regions.