Fluidigm of South San Francisco, Calif., has received US Patent No. 7,695,683, "Method and system for microfluidic device and imaging thereof." The patent describes a method of manufacturing a substrate. The substrate includes a rigid material that has a surface region capable of acting as a handle substrate, according to the patent. The substrate also has a deformable fluid layer coupled to the surface region. One or more well regions are formed in a first portion of the deformable fluid layer and are capable of holding a fluid.