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IP Roundup: Mar 9, 2010

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Rohm of Kyoto, Japan, has received US Patent No. 7,671,996, "Surface plasmon resonance sensor and biochip." The patent claims a surface plasmon resonance sensor that has a first dielectric layer, a metal layer disposed on the first dielectric layer, and a second dielectric layer covering the metal layer. The surface plasmon resonance sensor includes a sensor main body provided with an opening for exposing a part of a surface of the metal layer on a side facing the second dielectric layer, and for allowing a measurement sample to be brought into contact with this surface; a light source for introducing a beam into the metal layer from one end of the metal layer in a longitudinal direction of the metal layer; and a detection unit detecting a beam emitted from the other end of the metal layer.


The University of South Florida of Tampa has received US Patent No. 7,674,581, "Autonomous genosensor apparatus." The patent describes an autonomous genosensor apparatus for the analysis of ambient chemical, biochemical, biologic, biogenetic, and radiologic materials under field conditions in fluid or gaseous environments, such as marine or aquatic environments or industrial processes. Autonomous genosensors provide integral, self-contained units that automatically extract environmental samples, prepare those samples for analytical studies, analyze those samples using studies such as DNA or biomarker analysis, and store or transmit the data produced to a remote computer or computer network, according to the patent.


Boston Probes of Bedford, Mass., has received US Patent No. 7,674,585, "Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation." The patent describes a method for the block synthesis of combination oligomers in the absence of a template. The method includes reacting a first oligomer block, a second oligomer block, and optionally a condensation reagent or reagents under condensation conditions to form a combination oligomer. The formed combination oligomer is capable of hybridizing to a target sequence without a gap or a gap base, where the first and second oligomer blocks are each independently a peptide nucleic acid oligomer, PNA chimera, or PNA combination oligomer; neither of the first nor the second oligomer block is support bound; and the combination oligomer forms in the absence of a template.


Affymetrix has received US Patent No. 7,674,587, "Polymorphism detection." The patent describes a method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods employ arrays of oligonucleotide probes that are complementary to target nucleic acids that correspond to the marker sequences of an individual. The probes are typically arranged in detection blocks, each block being capable of discriminating the three genotypes for a given marker, for instance, the heterozygote or either of the two homozygotes, according to the patent. The method allows for automatable analysis of genetic linkage to even complex polygenic traits, the inventors claim.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.