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IP Roundup: Mar 2, 2010

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Samsung Electronics has received US Patent No. 7,670,772, "Microfluidic chip for multiple bioassay and method of manufacturing the same." Microfluidic channels are first formed by coupling a channel structure that includes grooves for sample channels and probe channels in a bottom surface and a substrate. Probe immobilization regions are then formed at intersections between the probe channels and the sample channels. Finally, blocking walls are formed in the probe channels before and after each of the probe immobilization regions to prevent mixing of target sample. Since the probes are immobilized in the microfluidic channels after the formation of the microfluidic channels, difficulty in connecting fluidic channels after the immobilization of probes on a substrate is alleviated, according to the inventors.


Goodgene of Seoul, Korea, has received US Patent No. 7,670,774, "Probe of human papillomavirus and DNA chip comprising the same." The patent describes oligonucleotide probes for analyzing 40 types of human papillomavirus, as well as a DNA chip produced by using the oligonucleotide probes. These DNA chips can analyze the 40 types of HPV found in the cervix and diagnose a complex infection by at least one type of HPV, according to the inventors.


Illumina has received US Patent No. 7,670,810, "Methods and compositions for whole genome amplification and genotyping." The patent provides methods of amplifying genomic DNA to obtain an amplified representative population of genome fragments. Methods are also provided for obtaining amplified genomic DNA representations of a desired complexity. Methods for simultaneously detecting large numbers of typable loci for an amplified representative population of genome fragments are also claimed.


Suntory of Osaka, Japan, has received US Patent No. 7,670,828, "Screening method for genes of brewing yeast." The patent claims a method for detecting genes associated with a desired brewing character by using a DNA array of the whole genome sequences of industrial yeast. Also provided are a method for yeast breeding; a method of producing an alcoholic beverage with improved quality; and a screening method to identify genes that increase productivity and improve flavor in the production of an alcohol or an alcoholic beverage.


Biochain Institute of Hayward, Calif., has received US Patent No. 7,670,833, "High throughput analysis for molecular fractions." The patent describes a high-throughput array platform for analyzing molecular fractions. Molecules are first fractionated according to the properties of molecules and are assigned primary designated orders while their tissue origins are assigned secondary designated orders so that each fractionated molecule becomes addressable and traceable, according to the patent. The fractionated molecules are then recovered, arrayed, and analyzed according to the same primary designated orders and secondary designated orders in a high throughput manner.

The Scan

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.

Study Tracks Outcomes in Children Born to Zika Virus-Infected Mothers

By following pregnancy outcomes for women with RT-PCR-confirmed Zika virus infections, researchers saw in Lancet Regional Health congenital abnormalities in roughly one-third of live-born children.

Team Presents Benchmark Study of RNA Classification Tools

With more than 135 transcriptomic datasets, researchers tested two dozen coding and non-coding RNA classification tools, establishing a set of potentially misclassified transcripts, as they report in Nucleic Acids Research.

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.