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IP Roundup: Feb 23, 2010


Fluidigm of South San Francisco, Calif., has received US Patent No. 7,666,361, "Microfluidic devices and methods of using same." The patent claims elastomeric-based microfluidic devices and methods for manufacturing and using them. Some of the devices have arrays of reaction sites to support high-throughput analyses, according to the patent. Some devices also include reaction sites located at the end of blind channels where reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be used with a variety of heating devices and can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping, and gene-expression analyses, according to the patent.

Samsung Electronics has received US Patent No. 7,666,603, "Breast cancer related protein, gene encoding the same, and method of diagnosing breast cancer using the protein and gene." The patent claims a method of detecting the presence of breast cancer in a test sample by: a) determining the expression level of an RNA in a test sample isolated from breast tissue from a human, where the RNA encodes a protein consisting of a claimed sequence; b) determining the expression level of the RNA in normal breast tissue; and c) detecting that breast cancer is present in the test sample when the RNA expression level is increased compared to the RNA expression level of the RNA encoding the protein consisting of the claimed sequence in normal breast tissue.

Samsung Electronics has also received US Patent No. 7,667,032, "Method of manufacturing a microarray." The patent claims a method of manufacturing a microarray by: a) providing a substrate with a surface that is immobilized with a functional group protected with an acid-labile protecting group and capable of coupling with an oligomer probe; b) providing a photoacid generator onto the substrate; c) disposing on the substrate an imprint template that includes a convex region surrounded by concave regions; d) exposing the reaction zones to light so that an acid is generated by the photoacid generator in the exposed reaction zones and a functional group in the exposed reaction zones is deprotected by the acid; and e) introducing an oligomer probe onto the substrate so that the oligomer probe couples with the deprotected functional group.

Autogenomics of Carlsbad, Calif., has received US Patent No. 7,666,819, "Integrated micro array system and methods therefor." The patent describes an integrated microarray system that enables automated sample processing and detection or quantification of nucleic acid and protein samples in a single analytical device. According to the patent, the system includes a housing unit, a fluidics station, a sample station, a pipette tip storage area, and a magazine holder. The system also includes a sample-processing platform, a stringency station, and optical detector, and a data transfer device.

AlleLogic Biosciences of Hayward, Calif., has received US Patent No. 7,667,024, "Oligonucleotides labeled with a plurality of fluorophores." The patent claims methods for designing labeled nucleic acid probes and primers by labeling oligonucleotides with spectrally identical or similar dyes and optionally with one or more quencher dyes. The labeled oligonucleotides exhibit a detectable increase in signal, according to the patent.

Genomics USA has received US Patent No. 7,667,026, "Population scale HLA-typing and uses thereof." The patent describes a portable system for real-time, population-scale human leukocyte antigen genotyping and allelotyping in a field environment. Also provided are HLA gene-specific primers and HLA allele-specific or SNP-specific hybridization probes. The patent also claims a microarray composed of the hybridization probes and a kit comprising the HLA gene-specific primers and the microarray.

NGK Insulators of Nagoya, Japan, has received US Patent No. 7,667,194, "Method of producing microarray." The method includes: a) ejecting a liquid sample from an outlet onto an inspection carrier to form inspection spots; b) inspecting the inspection spots for their quality to determine whether the inspected spots are defective or successful; c) making the detected defective discharge unit stop discharging the liquid sample to prevent the formation of the defective sample spot; and d) forming successful sample spots on the carrier using the successful discharge units.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.