Agilent Technologies has received US Patent No. 7,645,578, "Cleavage of RNA at redundant sites." The patent describes methods for treating samples of RNA. The method includes contacting the sample of RNA with a set of oligodeoxynucleotides to provide a DNA-RNA duplex. The DNA-RNA duplex is then contacted with an enzyme having a DNA:RNA nuclease activity to provide a digested RNA sample. Kits are also described.