Rosetta Genomics of Rehovot, Israel, has received US Patent No. 7,592,441, "Liver cancer-related nucleic acids." The patent claims microRNAs, miRNA precursors, and associated nucleic acids that can be used for diagnosis, prognosis, and treatment of liver cancer. Also described are methods that can be used to identify modulators of the disease-associated polynucleotides. Methods and compositions for linear amplification and labeling of a targeted nucleic acid are also provided.