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IP Roundup: Feb 24, 2009

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The California Institute of Technology of Pasadena has received US Patent No. 7,494,555, "Microfabricated elastomeric valve and pump systems." The patent claims a method of fabricating an elastomeric structure by: a) forming a first elastomeric layer on top of a first micromachined mold, where the first micromachined mold has a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; b) forming a second elastomeric layer on top of a second micromachined mold, where the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; c) bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and d) positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.



Beckman Coulter
has received US Patent No. 7,494,776, "Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands." The patent claims methods for determining the presence of an analyte in a sample, in which a capture agent is bound to the analyte at a first epitope and a detection agent is bound at a second epitope, and in which the detection agent includes an oligonucleotide to which a labeled, complementary oligonucleotide can be hybridized.
Genisphere of Montvale, NJ, has received US Patent No. 7,494,789, "Methods for amplification of nucleic acid sequences using staggered ligation." The patent claims methods and kits for producing sense RNA molecules. The sense RNA molecules are prepared by: a) providing a single-stranded cDNA molecule having 5' and 3' ends; b) attaching an oligodeoxynucleotide tail to the 3' end of the single-stranded cDNA molecule; c) providing a double-stranded RNA polymerase promoter having a sense strand and antisense strand, where the sense strand comprises a single stranded 3' overhang including a sequence complementary to said oligodeoxynucleotide tail; d) annealing the double-stranded RNA polymerase promoter to the oligodeoxynucleotide tail by complementary base pairing with the 3' overhang sequence; e) ligating the 5' end of the antisense strand of the double-stranded RNA polymerase promoter to the 3' end of the oligodeoxynucleotide tail; and f) initiating RNA transcription using an RNA polymerase which recognizes the double-stranded promoter, thereby producing a sense RNA molecule.
Seiko Epson of Tokyo has received US Patent No. 7,494,206, "Liquid ejection head and method of producing same." The patent claims a method of producing a liquid ejection head The head includes: a) a flow path-forming substrate in which a space including pressure-generating chambers and an ink reserving chamber is formed; b) a nozzle plate which is stacked on one face of the flow path forming substrate; and c) a vibration plate which is stacked on the other face of the flow path-forming substrate.
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