Northwestern University has received US Patent No. 7,569,340, "Nanoarrays of single-virus particles, methods, and instrumentation for the fabrication and use thereof." The patent claims a nanoarray template that uses coordination chemistry or metal-ion binding to control the site-isolation and orientation of virus particles. The nanoarray template is generated by lithography including dip pen nanolithography, the patent states. According to the inventors, coordination chemistry is used to immobilize individual virus particles without the need for their genetic modification. Single-particle control enables a wide variety of studies involving viruses, including single-particle or single-cell infectivity studies and studies aimed at understanding how surface presentation influences their bioactivity.
Sierra Molecular of Sonora, Calif., has received US Patent No. 7,569,342, "Removal of molecular-assay interferences." The patent claims methods and systems for removing masking agents from test samples, such as DNA-containing samples obtained from living subjects, when they are submitted for or subjected to molecular assays. According to the patent, masking agents are suppressed by contacting a test sample with an amount of one or more divalent metal chelators and an amount of one or more chelator enhancing components. The amounts of the divalent metal chelators and the chelator-enhancing components are selected so that the interference of a masking agent on a molecular assay of a nucleic acid-containing test sample is suppressed.
Rosetta Inpharmatics of Seattle has received US Patent No. 7,569,343, "Methods to assess quality of microarrays." The patent claims methods and compositions for assessing the quality of microarrays. It describes the use of quality-control probes that are synthesized on the microarray monomer by monomer in a step-by-step synthesis. By assessing the degree of signal from the quality-control probes and determining their deviation from expected signal intensities, the quality of microarray synthesis can be ascertained, according to the inventors. Also claimed is a method of using a computer to identify microarrays that have had a defect or defects during synthesis, storage, or processing.
OnChip Cellomics Consortium of Tokyo has received US Patent No. 7,569,354, "Cellomics system." The patent claims a method of labeling a cell. According to the described method, a specific labeling material present on a surface of a target cell is taken in the cell via a transporter, and the cell is dispersed one by one to separate the same with a cell separator. After the separation, the cell is put in a solution not containing the specific labeling substance to remove the specific labeling substance taken in the cell. This series of steps is continuously conducted with a cell-separation chip.
Vanderbilt University of Nashville, Tenn., has received US Patent No. 7,569,392, "Multiplex spatial profiling of gene expression." The patent describes mass-tag complexes that permit the simultaneous obtainment of information related to biological molecules. The biological molecules may be RNA or protein, and the information includes both levels of expression as well as spatial disposition within a cell or tissue, the inventors state. The mass tag comprises a core structure, a target-binding structure, a cleavable linker and a mass tag that exhibits a unique mass spectroscopy signal, according to the patent.
Enzo Life Sciences of Farmingdale, NY, has received US Patent No. 7,569,695, "Dyes for the detection or quantification of desirable target molecules." The patent describes dyes for the quantification of desirable target molecules, such as proteins and nucleic acids. The dyes may be used in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also claimed that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The described dyes have been modified by the addition of charged and polar groups to provide beneficial properties, according to the inventors.