The Chinese Academy of Sciences of Liaoning has received US Patent No. 7,560,030, "Method for separation and enrichment of phosphopeptides." The patent describes a method for phosphopeptide isolation and enrichment. The method is based on the interaction between zirconium phosphonate and phosphopeptide. According to the patent, zirconium phosphonate is immobilized on the surface of matrix for phosphopeptide enrichment. It also could be immobilized on chip surface, as well as a chromatographic matrix for isolation and purification of phosphopeptides.