Qiagen has received US Patent No. 7,553,619, "Detection method using dissociated rolling circle amplification." The patent claims methods for detecting small quantities of analytes such as proteins and peptides. The method involves associating a DNA circle with the analyte and the subsequent release and rolling circle replication of the circular DNA molecule. More specifically, an amplification target circle is associated with analytes using a conjugate of the circle and a specific binding molecule that is specific for the analyte to be detected.