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IP Roundup: May 5, 2009


The National Institute of Advanced Industrial Science and Technology of Tsukuba, Japan, and Dainippon Screen of Kyoto, Japan, have received US Patent No. 7,527,692, "Processing apparatus which performs predetermined processing while supplying a processing liquid to a substrate." The patent describes a substrate holder, above which is positioned: a) a fluid jet nozzle that is capable of injecting drops of a solution having "ordinary particle diameters"; b) a fine-fluid jet nozzle that is capable of injecting drops of a solution having "fine particle diameters" which are smaller than the ordinary particle diameters; and c) a regular reflection laser displacement gauge. According to the patent, these three nozzles are attached on the same plate and form a print head.

The University of California of Oakland has received US Patent No. 7,527,934, "Labeled substrate conjugates for identifying enzyme inhibitors." The patent claims methods of using labeled substrate conjugates to screen for enzyme inhibitors in a high-throughput format. Specifically, the patent provides a detectable label-substrate conjugate comprising a detectable label covalently attached to the substrate of an enzyme. Also claimed is a method of identifying an enzyme inhibitor, specifically a neuraminidase or a sialyltransferase inhibitor, by combining in an assay mixture an assay complex and a sufficient quantity of the enzyme to react with the substrate under noninhibitory conditions. The detection of a change in the label upon combining with the enzyme indicates the absence of an enzyme inhibitor. The assay complex is designed so that the presence of an enzyme inhibitor prevents the enzyme from modifying the substrate and causing a change in the detectable label. As such, test ligands which prevent a detectable change in the label can be identified as enzyme inhibitors, the patent claims.

Vidar Systems of Herndon, Va., has received US Patent No. 7,528,374, "Sensing apparatus having optical assembly that collimates emitted light for detection." The patent claims an apparatus for optical sensing of samples. The apparatus includes an optical source, an optical assembly, a sample holder, an objective lens, and a detector. The objective lens collimates light emitted by the sample and, preferably, the optical assembly rotates about an axis, allowing the sensing apparatus to sense results from plural locations on a sample without moving the sample, the patent states. Moving the sample in a linear direction while rotating the optical assembly allows sensing of an entire sample and light from the optical source enters the optical assembly along the axis of rotation.

The Scan

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.

Effectiveness May Decline, Data From Israel Suggests

The New York Times reports that new Israeli data suggests a decline in Pfizer-BioNTech SARS-CoV-2 vaccine effectiveness against Delta variant infection, though protection against severe disease remains high.

To See Future Risk

Slate looks into the use of polygenic risk scores in embryo screening.

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.