SRU Biosystems of Woburn, Mass., has received US Patent No. 7,524,625, "Real time binding analysis of antigens on a biosensor surface." The patent provides methods for detecting interactions between phage and antigen or antigen and antibody using biosensors. The method includes: a) immobilizing a phage preparation on a biosensor, where the preparation is immobilized to the biosensor by an antibody specific for a phage coat protein or an antibody fragment specific for a phage coat protein, and where the antibody or antibody fragment comprises a tag; b) contacting the biosensor with the binding partner; and c) detecting binding of the binding partner to the phage immobilized on the biosensor.
Samsung Electronics has received US Patent No. 7,524,662, "Method of storing substrate having active group or probe molecule immobilized thereon using UV film, method of producing microarray using the UV film, and substrate having the UV film attached thereto." The patent claims a method of storing a substrate that has an active group or a probe molecule immobilized on it. The method includes attaching a UV film to a surface of the substrate, and exposing the UV film to UV light. According to the patent, the film should comprise a UV-permeable base film and a pressure-sensitive adhesive layer. When this layer is exposed to UV light, its adhesive force decreases. The patent also claims a method of producing a microarray by: a) attaching a UV film to a surface of a substrate having a probe molecule immobilized on it in predetermined regions, where the probe molecule is selected from the group consisting of a nucleic acid, a protein, and a polysaccharide; b) exposing the UV film to UV light; and c) dicing the substrate with the attached UV film to obtain a unit microarray.
Sandia Corp. of Livermore, Calif., has received US Patent 7,524,672, "Microfluidic microarray systems and methods thereof." The patent claims systems that include a manifold in fluid communication with a microfluidic chip having a microarray, an illuminator, and a detector in optical communication with the microarray. Methods for using these systems for biological detection are also described.
Agilent Technologies has received US Patent No. 7,524,942, "Labeled nucleotide composition." Embodiments of labeled nucleotide compositions are described in the patent. Methods are also described in which a sample containing RNA is contacted with an enzyme having an RNA ligation activity in the presence of a labeled nucleotide composition to provide labeled RNA. Methods of performing an array analysis of a labeled RNA sample are also claimed.
BioArray Solutions of Warren, NJ, has received US Patent No. 7,526,114, "Analysis, secure access to, and transmission of array images." Systems and methods are claimed for the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results, the patent states. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
Fluidigm of South San Francisco, Calif., has received US Patent No. 7,526,741, "Microfluidic design automation method and system." The patent claims a microfluidic circuit design method. The method includes developing synthesizable computer code for a design. Next, a microfluidic circuit schematic, including a plurality of symbols for microfluidic components, is generated either interactively or using the synthesizable computer code. The microfluidic circuit schematic is then functionally simulated. The microfluidic components are placed and routed on a template to form a physical layout. Then the physical layout is physically simulated using dynamic simulation models of the microfluidic components; and the physical layout is written to a layout file.