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IP Roundup: Apr 26, 2011

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Epigenomics of Berlin has received US Patent No. 7,932,027, "Method for determining the methylation pattern of a polynucleic acid." According to the patent, a solution containing a mixture of fragments of a polynucleic acid is first prepared. Then the solution is coupled with a detectable substance and contacted with a DNA microarray containing different immobilized oligonucleotides, each comprising one methylation site, under conditions affording hybridization. A washing step may then be performed, followed by detection of which fragments are hybridized and which fragments are not hybridized.


Toray Industries of Tokyo and Kyoto University of Kyoto, Japan, have received US Patent No. 7,932,032, "Method for diagnosing esophageal cancer." The patent claims a chip of polynucleotide and antibody probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer. A method for monitoring the presence or metastasis of esophageal cancer using the array is also claimed.


PerkinElmer of Waltham, Mass., has received US Patent No. 7,932,037, "DNA assays using amplicon probes on encoded particles." The patent describes encoded bead multiplex assays for chromosomal gains and losses that provide the benefits of complex, large template DNA sources, such as bacterial artificial chromosome DNA, as the probe material without bead networking or other assay performance problems. Reagents for assaying DNA are also described, which include encoded particles having attached amplicons amplified from a template DNA sequence.


Harvard University of Cambridge, Mass., has received US Patent No. 7,932,213, "Small molecule printing." An array of chemical compounds attached to a solid support is described, where the density of the array of compounds is at least 1,000 spots per centimeter. The arrays are generated by: providing a solid support functionalized with a selected chemical moiety capable of interacting with a chemical compound to form an attachment and delivering compounds to the solid support having the described density. Methods for using these arrays to identify small molecule partners for biological macromolecules of interest are also claimed.


Samsung Electronics of Seoul, Korea, has received US Patent No. 7,932,368, "Multiple SNP for diagnosing colorectal cancer, microarray and kit comprising the same, and method of diagnosing colorectal cancer using the same." Multiple SNPs for colorectal cancer diagnosis, a microarray, and a kit including a polynucleotide having the SNPs, are claimed. A method of diagnosing colorectal cancer using the SNPs is also described. According to the patent, the provided array substrate is composed of a material selected from the group consisting of silicon wafer, glass, quartz, metal, and plastic.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.