Bio-Rad Laboratories has received US Patent No. 7,517,496, “Latex based adsorbent chip.” The patent describes an adsorbent chip, which includes a substrate, an intermediate layer of linker arms, and an adsorbent film, which is attached to the linker arms. The adsorbent film is made up of adsorbent particles, each of which includes a binding functionality. The patent also provides a method of making the chips, in which the substrate-intermediate film cassette is formed and the adsorbent film is subsequently immobilized. When the adsorbent film is from the same preparation across a particular batch of chips, the chips provide for the acquisition of data that are highly reproducible from one chip to the next throughout the particular batch of chips. The patent also provides a method for detecting an analyte in a sample by contacting the analyte with the adsorbent biochip to allow the capture and detection of the analyte. In one embodiment, the analyte is labeled fluorescently, and is detected on the chip by a detector of the label, such as a CCD array.
Agilent Technologies has received US Patent No. 7,517,498, “Apparatus for substrate handling.” The patent claims devices, apparatus, and methods for carrying out processing steps involved in chemical reactions such as hybridization reactions conducted on the surface of a substrate. The device includes a housing, a housing chamber, and an opening through which a substrate may be inserted into the housing chamber. The device may also include a lift mechanism for moving the substrate in and out of the housing chamber in a controlled manner. At least one inlet may be in fluid communication with the housing chamber and at least one outlet may be in fluid communication with the housing chamber. Also described are methods where the surface is brought into contact with a processing fluid; and then the surface is removed from contact with the fluid in a controlled manner at a rate that substantially eliminates droplet formation of the fluid on the surface of the substrate.
Samsung Electronics has received US Patent No. 7,517,650, “Method of diagnosing breast cancer and compositions therefor.” The patent claims a method of diagnosing breast cancer in an individual aged younger than 41 or older than 54. The method includes obtaining a nucleic acid from the individual and determining a nucleotide at a polymorphic site of the nucleic acid. Polynucleotides specific to breast cancer, a microarray comprising the polynucleotides, and diagnostic kits are also claimed.
Maven Technologies of Los Angeles has received US Patent No. 7,518,724, “Image acquisition, processing, and display.” The patent claims an apparatus for imaging, including: a) a light source emitting a polarized light beam; b) an optical assembly including a light reflection surface, where the light beam from the light source is reflected by the light reflection surface to provide an evanescent field adjacent the light reflection surface. The light-reflection surface is adapted to allow the placement of a specimen array so that the specimen array in the evanescent field causes spatially distributed polarization changes in the cross-section of the light beam; c) a two-dimensional array detector positioned to detect the spatially distributed polarization changes caused by the specimen array; and d) a processor operably coupled to the two-dimensional array detector, the processor processing data from the two-dimensional array detector to provide a two-dimensional representation of the spatially distributed polarization changes occurring in the specimen array in real time.