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IP Roundup: Jan 27, 2009


Tigenix of Leuven, Belgium, has received US Patent No. 7,482,114, “In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation.” The patent claims an in vivo assay to measure anchorage-independent growth and phenotypic stability of a certain cell population. The assay includes the subcutaneous or intramuscular injection in a mammal of a cell suspension of articular chondrocytes in an iso-osmotic liquid. The patent also claims DNA chips and diagnostic tools to predict the outcome of ACT. According to the patent, antibodies raised against positive and negative markers of chondrocyte stability can also be used for quality control on the chondrocytes.

Roche NimbleGen has received US Patent No. 7,482,170, “Parallel loading of arrays.” The patent claims a method for loading samples on a microarray to perform hybridization reactions. The method includes the steps of: a) placing the samples to be loaded onto a sample-loading array in aligned subarrays spaced apart from the microarray until the hybridization reactions are performed; and b) placing the sample- loading array in contact with the microarray under conditions so that molecules in the samples can hybridize to probes in the aligned sub-arrays.

Nanosphere of Northbrook, Ill., has received US Patent No. 7,482,173, “Method for attachment of silylated molecules to glass surfaces.” The patent claims a method for the immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.

GeneTag Technology
of Atlanta has received US Patent No. 7,482,443, “Systems and methods to quantify and amplify both signaling probes for cDNA chips and genes expression microarrays.” The patent describes a series of reagent compositions and methods for making and amplifying novel cDNA-based probe sets from RNA samples to improve analysis with gene-expression arrays. The methods produce probe sets with common universal linkers at one or both ends, called wrap-probes, where the linkers do not bind to the target sequences and they can efficiently bind added reporters to the probes. The universal linkers are also designed as primer binding sites for copying and amplifying the probes, either linearly with one linker, or exponentially with double linkers.
The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.