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Institute for Molecular and Cell Biology, National Cancer Institute, New York State, Expression Analysis, WM Keck Center for Comparative and Functional Genomics, Axon, Samsung, Cytogenomics

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In Singapore, Zebrafish Markers Extend Beyond Stripes

Scientists at Singapore’s Institute for Molecular and Cell Biology, led by Peng Jinrong, principal investigator with the institute’s functional genomics lab, and Wen Zilong, a molecular biologist, have identified and isolated 15,000 of the genetic markers for the zebrafish, according to a report this week in The Straits Times, a Singapore newspaper. The scientists are creating a microarray based on the sequence information identified.

 

Zeroing in on Gene Activity of Hepatocellular Carcinoma

Researchers at the National Cancer Institute, in collaboration with the Liver Cancer Institute of Fudan University in Shanghai, have used microarray analysis to identify a pattern of gene activity unique to hepatocell-ular carcinoma cells that metastasize.

In a report pubished in Nature Medicine this week, the researchers said they have identified a specific gene, osteopontin, required for metastasis. The research found that genes expressed in metastatic tumors were identical to those in the original tumor, challenging the current model of metastasis progression.

The research project involved the analysis of more than 9,000 genes within tumor cells.

 

New York State Funding for Optical Biochip Water Sensor

New York Gov. George Pataki announced last week that the College of Enviromental Science and Forestry in Syracuse will receive $300,000 in state funding and another $725,000 in federal money for biochip research conducted by Sentinel LLC, a business collaboration of Illumination Technologies and the Syracuse firm of O’Brien & Gere.

The business is creating an optical biochip that would be used to monitor the presence of dangerous biological and chemical agents in water supplies.

 

Expression Analysis Allies with Cardinal Health

Durham, NC-based Expression Analysis, a micro-array analysis provider, announced last week a strategic alliance with Cardinal Health of Dublin, Ohio, a pharmaceutical services provider.

Under the alliance, Cardinal will offer Expression Analysis’s Affymetrix-based microarray analysis for the purpose of drug discovery research. Financial details were not disclosed.

 

Keck Center Offers University of Illinois MicroArray Statistical Consulting

The Illinois statistic office of the department of statistics at the University of Illinois at Urbana-Champaign last week introduced a consulting service conducted in collaboration with the WM Keck Center for Comparative and Functional Genomics.

The services, targeting members of the academic community, will offer data storage and management, preprocessing of microarray data, experimental design, data mining, hypothesis testing, and grant-writing assistance.

 

Axon Reports Loss for 2002

Melbourne, Australia-based Axon Instruments reported after-tax losses of $9.5 million in giving its financial results for 2002 last week.

The company said sales for the year ended Dec. 31, 2002, decreased 23 percent to $27.5 million, compared to $35.7 million in 2001.

According to a report published by the Australian Associated Press, the company, which makes a popular line of microarray instrumentation, blamed the shortfall partially on a decreased demand for microarray analysis products resulting from a slowdown in the growth of demand for the technology. Also cited were slower than anticipated product rollouts, high engineering expenses for new products in development, one-time charges of $1.8 million, and the downturn in the world economy.

 

Samsung to Roll Out New Substrate Array

Seoul, South Korea-based Samsung SDI last week announced that it has developed a new substrate for microarray chips, derived from technology developed for its display products, and plans to sell more than 300,000 units this year, according to a report by Agence France Presse.

 

Midwest Scientific, Cytogenomics in Deal

Bioinformatics startup Cytogenomics announced this week a partnership with lab equipment supplier Midwest Scientific to distribute its SilicoCyte microarray analysis software.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.