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Industrial Technology Research Institute, Boston Probes, Nanogen


Industrial Technology Research Institute of Hsinchu, Taiwan, received US Patent No. 6,528,291, “Activated inorganic slide having aldehyde groups deposited by plasma.” The patent covers a method for using plasma deposition to create an active slide, which is usable for microarrays, with a layer of actively functional groups of polymers.


Boston Probes of Medford, Mass., received US Patent No. 6,528,267, “Methods, kits and compositions pertaining to PNA molecular beacons.” The patent covers a system for creating PNA molecular beacons, which are self-complementary arm segments, and flexible linkages for molecular interactions. In the absence of a target sequence, PNA molecular beacons facilitate energy transfer between the linked donor and acceptor moieties of the probe, and can be used in microarray analysis.


Nanogen of San Diego received US Patent No. 6,524,517, “Methods for molding and grafting highly uniform polymer layers onto electronic microchips.” The patent covers a system for creating microreaction molds, from materials such as etched silica, or multicomposite, such as quartz/metal, and methods for molding uniform thin films onto substrates. The molds can be used to generate thin polymeric films onto microchip substrates, and can be used to create microarrays.

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.