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Industrial Technology Research Institute, Boston Probes, Nanogen


Industrial Technology Research Institute of Hsinchu, Taiwan, received US Patent No. 6,528,291, “Activated inorganic slide having aldehyde groups deposited by plasma.” The patent covers a method for using plasma deposition to create an active slide, which is usable for microarrays, with a layer of actively functional groups of polymers.


Boston Probes of Medford, Mass., received US Patent No. 6,528,267, “Methods, kits and compositions pertaining to PNA molecular beacons.” The patent covers a system for creating PNA molecular beacons, which are self-complementary arm segments, and flexible linkages for molecular interactions. In the absence of a target sequence, PNA molecular beacons facilitate energy transfer between the linked donor and acceptor moieties of the probe, and can be used in microarray analysis.


Nanogen of San Diego received US Patent No. 6,524,517, “Methods for molding and grafting highly uniform polymer layers onto electronic microchips.” The patent covers a system for creating microreaction molds, from materials such as etched silica, or multicomposite, such as quartz/metal, and methods for molding uniform thin films onto substrates. The molds can be used to generate thin polymeric films onto microchip substrates, and can be used to create microarrays.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.