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Industrial Technology Research Institute, Affymetrix, Genolife, Xtrana


Industrial Technology Research Institute (ITRI) of Taiwan received US Patent No. 6,605,363, “High-density functional slide and preparation method thereof.” The patent covers a system for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an organic or inorganic substrate, respectively. The resulting slide is useful in the preparation of highly homogeneous functional-group slides and the high-density and high-efficiency biochip/microarrays.


Affymetrix received US Patent No. 6,604,902, “Cartridge loader and methods.” The patent covers a device for transporting cartridges into a scanner in a temperature-controlled environment. The transport system has a mechanism for grasping cartridges, a holding station to store cartridges after removal from the scanner, and a barcode reader.


Genolife of Gerzat, France, received US Patent No. 6,605,435, “Method for amplifying all of the DNA fragments in a sample, including small and damaged fragments, by pretreating the fragments with P1 nuclease.” The patent covers a method of amplifying all of the DNA fragments of a sample, including fragments that are small or damaged. The invention comprises an initial step of generating a free 3’-OH end with P1 nuclease. The method also provides for extraction of the DNA fragments from a sample and reduction of their size to between 100 and 300 base pairs. A poly(dX) oligonucleotide is added to the 3’ ends of the DNA fragments using a terminal transferase, and the DNA is denatured and hybridized to a poly(dY) primer complementary to the poly(dX) ends. Finally, the DNA is polymerized with DNA polymerase. The resulting DNA can be amplified by denaturing and slowly renaturing the complementary strands.


Xtrana of Broomfield, Colo., received US Patent No. 6,605,451, “Methods and devices for multiplexing amplification reactions.” The patent covers methods, reagents, compositions, kits, and instruments for use in simultaneously amplifying multiple targets. The invention is based on the discovery of a two-step multiplex amplification reaction wherein the first step truncates the standard initial multiplex amplification round to boost the sample copy number by only a 100-1000 fold increase in targets.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.