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Illumina, Roche NimbleGen

Illumina last week launched its Infinium HD Human660W-Quad BeadChip.
The Human660W is a four-sample array that features 2.6 million genetic markers and was developed in collaboration with the Centre for Applied Genomics at the Hospital for Sick Children and the Wellcome Trust Sanger Institute.
The Human660W-Quad BeadChip builds on the content from Illumina's HumanHap550+ BeadChip to target over 5,000 regions in the human genome known to be associated with copy number variation. Illumina expects to begin shipping the Human660W-Quad next month.

Roche NimbleGen last week launched HD2 arrays and services for chromatin immunoprecipitation studies.
The 2.1 million feature NimbleGen ChIP-chip HD2 arrays provide more than a five-fold increase in probe density per array compared to its previous generation of arrays, with increased coverage of biological features such as promoters and CpG islands, the company said.
The new set of arrays includes the Human Deluxe Promoter array, which allows researchers to interrogate all known and alternative start site promoters at 10-kilobase promoter coverage, as well as all annotated CpG islands, and microRNA promoters on a slide. Whole-genome tiling sets for human, mouse, rat, D. melanogaster, and C. elegans are also available as either 10-array sets or 4-array sets.

The Scan

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.

Study Tracks Outcomes in Children Born to Zika Virus-Infected Mothers

By following pregnancy outcomes for women with RT-PCR-confirmed Zika virus infections, researchers saw in Lancet Regional Health congenital abnormalities in roughly one-third of live-born children.

Team Presents Benchmark Study of RNA Classification Tools

With more than 135 transcriptomic datasets, researchers tested two dozen coding and non-coding RNA classification tools, establishing a set of potentially misclassified transcripts, as they report in Nucleic Acids Research.

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.