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Illumina, The Provost, Fellows and Scholars of the College of the Holy & Undivided, Metal Industries Research and Development Center, National Taiwan University, Novartis, Paradigm Genetics


Illumina of San Diego, received US Patent No. 6,770,441, “Array compositions and methods of making same.” The patent relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods of making and using the composite arrays and covers a hybridization chamber for use with a composite array.

The Provost, Fellows and Scholars of the College of the Holy & Undivided of Dublin, Ireland, received US Patent No. 6,770,434, “Biological assay method.” Biological assays using various constructions of biochips are disclosed to mirror in vivo situations. The biochip 50 comprises a microchannel having a liquid outlet port, bubble release port, and a liquid outlet port with an associated bubble release port. A multiplicity of tests can be performed often by coating the bore of the microchannel with various adhesion-mediating proteins or the use of chemoattractants. The assay assembly comprises a syringe pump feeding the biochip. An inverted microscope, digital camera, and recorder are provided. A sample liquid containing cells in suspension is injected slowly through the biochip and the effect of the assay recorded over a long period.

Metal Industries Research and Development Center of Taiwan, received US Patent No. 6,769,760, “Microarray printing device.” The patent covers a microarray printing device including an elongated holder with a plural-ity of receiving slots and a plurality of printing pins. Each of the printing pins extends through and is linearly movable in a respective slot in the holder, and has head, tip, and shank portions. The shank portion has a surface formed with at least one longitudinal flute extending from the head portion to the tip portion.

National Taiwan University of Taipei, received US Patent No. 6,768,122, “Multiphoton excitation microscope for biochip fluorescence assay.” The patent covers a multiphoton excitation microscope for simultaneously detecting differently colored fluorescence materials on biochips and includes a multiphoton excitation source, objectives, and a plurality of detection channels. The biochip is hybridized and labeled with fluorescence materials for expressing hybridized biological signals. The multiphoton excitation source is focused to a light spot on the biochip to excite the fluorescence materials bound to it. After that, the fluorescence emission at different wavelengths from the different fluorescent materials is detected by the plural detection channels.

Novartis of Basel, Switzerland, received US Patent No. 6,771,376, “Sensor platform, apparatus incorporating the platform, and process using the platform.” The patent covers a sensor platform for use in sample analysis comprising a substrate of refractive index (n1) and a thin, optically transparent layer of refractive index (n2) on the substrate, where (n2) is greater than (n1). The platform incorporates one or multiple corrugated structures in the form of periodic grooves, which defines one or more sensing areas each for one or more capture elements. The grooves are so profiled, dimensioned and oriented that when coherent light is incident on the platform it is diffracted into individual beams or diffraction order resulting in reduction of the transmitted beam, and an abnormally high reflection of the incident light thereby creates an enhanced evanescent field at the surface of each sensing area. The amplitude of this field at the resonant condition is greater by an order of approximately 100 than the field of prior art platforms so that the luminescence intensity created from samples on the platform is also increased by a factor of 100. Also disclosed are an apparatus incorporating the platform and a method of using the platform. Further increases of amplitude have been detected by using light having a linear component which gives rise to TM excitation and/or irradiating the platform from the substrate side.

Paradigm Genetics of Research Triangle Park, N.C., received US Patent No. 6,770,452, “Methods for the identification of inhibitors of serine acetyltransferase activity in plants.” The patent covers methods for the identification of herbicides by measuring the activity of an SAT in the presence and absence of a compound, wherein an alteration of SAT activity in the presence of the compound indicates the compound as a candidate for an herbicide. The present inventors have discovered that serine acetyltransferase is essential for plant growth. Specifically, the inhibition of SAT gene expression in plant seedlings results in reduced growth and altered pigmentation. Thus, SAT is useful as a target for the identification of herbicides.


The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.