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Illumina, Agilent Technologies, BioDiscovery

Illumina this week announced that it has added a custom-content methylation product to its portfolio.
Investigators now have the option to select their favorite genes or gene regions to cost-effectively survey up to 1,536 methylation sites across 96 samples at the same time, Illumina said.
The company said that the custom offering could benefit researchers who are interested in methylation studies in areas such as cancer, developmental disorders, stem cell research, aging, and neurological diseases.
The custom offering follows Illumina’s GoldenGate Methylation Cancer Panel I, which was launched in January.

Agilent Technologies announced this week that it now offers 8-plex high-density microarrays with eight assays printed on a standard 1-inch x 3-inch glass slide. Each microarray can contain up to 15,000 oligonucleotides, and the company said the format permits reduced cost-per-experiment.
The 8-plex microarrays are available for a wide range of applications, including gene expression, array-based comparative genomic hybridization, microarray-based chromatin immunoprecipitation (ChIP)-on-chip, splice variants, and DNA methylation measurements, Agilent said.
In addition to the 8-plex format, Agilent offers a four-array-per-slide format with 44,000 features per array, and a two-array-per-slide format with 105,000 features per array.

BioDiscovery last week released GeneDirector 3.5, a microarray data analysis tool featuring extended data management support for Affymetrix, Illumina, and Agilent microarray platforms.
GeneDirector is now compatible with Affymetrix software technology using Fusion SDK and expression and genotyping data from Illumina's BeadStudio is now supported as well, BioDiscovery said. Additionally, high-density array support has been improved throughout the application enabling management and processing of Agilent's 244,000-feature arrays.
The software is also compatible with BioDiscovery's upcoming Array Results Manager version 2.0, which will be released at the American Association for Cancer Research 2007 Annual Meeting this week.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.