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Hitachi Software Engineering, Regents of the University of California, Artificial Sensing Instruments, Board of Regents University of Texas System, Baylor College of Medicine, Alfa Wassermann, Proteus

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Hitachi Software Engineering of Kanagawa, Japan, has received US Patent No. 6,818,400, “Process for producing biochip.” The invention aims at producing a biochip by an inkjet system without wasting a DNA solution. A biochip-producing solution is prepared to contain a combination of a DNA solution to be spotted on a plate and a low-cost buffer solution to be remained in the device after the production. The buffer solution used has a different specific gravity from that of the DNA solution and thus is not mixed with the DNA solution.


The Regents of the University of California of Oakland, Calif., have received US Patent No. 6,818,184, “Capillary array and related methods.” The patent covers methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sample through the channel to each successive binding partner so that target analyte present in said sample binds to the corresponding binding partner. The sample is then transported beyond the binding partner(s), followed by detection of any target analyte bound to each binding partner. In one embodiment, binding efficiency is increased by the use of segmented transport, wherein a first bolus or bubble of a fluid that is immiscible with the sample precedes the sample during transport and a second bolus or bubble of a fluid that is immiscible with the sample follows the sample. Many configurations are possible for the device of the invention. A preferred device includes a substrate with a channel formed in its surface, and a cover element that overlies and seals the channel. Binding partner(s) are affixed to the surface of the cover element facing the channel lumen.


Artificial Sensing Instruments of Zurich, Switzerland, has received US Patent No. 6,818,886, “Detection method.” The patent covers a method for detecting a substance or substances in a sample or in a matrix of samples combining detection methods that are, on the one hand, based on direct detection with integrated optical (bio)chemo-sensitive waveguide grating structures and, on the other hand, based on a mass-spectrometric detection effected by way of a desorption process. The method permits an increase in detection security and/or detection sensitivity.


The Board of Regents University of Texas System and The Baylor College of Medicine, both of Houston, have received US Patent No. 6,818,401, “Method of detection and interpretation of mutations through expression or function tests of haploid genes.” The patent relates to a method for detection and interpretation of loss-of-function or gain-of-function mutations for test genes of interest. The genes of interest include those associated with inherited genetic disorders. The present invention involves the process of obtaining a sample of genetic material from an individual in the form of tissue or cells, separation of the genetic material from the cells of the individuals into haploid sets by transferring the individual chromosomal entities into a population of target cells, and monitoring the target cell population for successful transfer and expression of the test genes of interest using various functional, immunological, and structural assays.


Alfa Wassermann of West Caldwell, NJ, has received US Patent No. 6,817,256, “Pipette sampling system.” The patent covers a pipette sampling system that allows for automated sampling from the contents of a capped sample tube. More specifically, the invention relates to a pipette tip, having a piercing tip attached thereto, for removal of aliquots of samples from capped sample tubes comprising said samples.


Proteus of Nimes, France, has received US Patent No. 6,818,396, “Process for determination of the activity of a substance using an in vitro functional test.” The patent concerns a method for determining the activity of a substance using a functional test, characterized by detection and/or measurement of the variation of a known function corresponding to one or several proteins produced in vitro in the presence and in the absence of said substances or to the substance in the presence or in the absence of one or several proteins produces in vitro.