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Hitachi Software Engineering, Applera Corporation, Agilent Technologies, Battelle Memorial Institute

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Hitachi Software Engineering of Kanagawa, Japan has received US Patent No. 6,869,763, “Microarray chip and method for indexing the same.” The patent covers a method for indexing a microarray chip with a plurality of spots arranged in a predetermined positional relationship comprising of: selecting some of the plurality of spots as index spots; spotting at least one biological element onto one of remaining spots as a non-index spot; indexing the microarray chip spotted with said biological element by selectively providing at least one kind of detective colorant onto the index spots thereby coding in the index spots a unique microarray index value, said microarray index value being linked to element information which includes a type of said biological element and a location of said non-index spot on the chip; and automatedly identifying the microarray chip by detecting said detective colorant provided on said index spots.

It also covers a method for indexing a microarray chip according, further comprising the steps of: constructing a database for storing an element information record, a microarray chip master record, and a biological element information record; recording information of the microarray chip on the microarray chip master record with a microarray index; linking the microarray chip with the microarray chip master record as well as the biological element information record via the microarray index coded in the index spots; and linking the biological element information record with the element information record via the element index.


Applera Corporation of Norwalk, Conn., has received US Patent No. 6,869,928, “Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins and uses thereof.” The patent covers an invention that provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter cofactor peptides of the invention. It specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter cofactor peptides, and methods of identifying modulators of the transporter cofactor peptides. These peptide sequences, and nucleic acid sequences that encode these peptides, can be used as models for the development of human therapeutic targets, aid in the identification of therapeutic proteins, and serve as targets for the development of human therapeutic agents that modulate transporter cofactor activity in cells and tissues that express the transporter cofactor. Experimental data as provided by Applera indicates expression in humans in placenta choriocarcinomas, ovary adenocarcinomas, retinoblastomas of the eye, brain neuroblastomas, endometrium adenocarcinomas, colon, lung small cell carcinomas, T-lymphocytes, ovarian tumors, pheochromocytomas, fetal liver/spleen, Burkitt’s lymphoma, and leukocytes.


Agilent Technologies of Palo Alto, Calif., has received US Patent No. 6,870,166, “Maximum sensitivity optical scanning system.” The patent covers a maximum sensitivity optical scanning system. Generally, it operates by scanning a sample, such as in a DNA microarray, at a setting calculated to result in signal saturation for some, but not all, available data. Preferably, scanning is accomplished at a maximum setting for a given scanning apparatus so that the weakest signal possibly detected may be observed. Sometimes complete signal saturation may result This condition indicates that no weak data is present. Whether or not data for weak signals is detected, one or more subsequent scans of the same area are taken at lower settings (in terms of detector attenuation and/or excitation light source gain) and data from at least those previously saturated regions is obtained.

This methodology works to preserve full signal sensitivity in taking data for the weakest signals. Another aspect of the invention provides for upward adjustment of scanning sensitivity, especially to obtain results when indication is received that a decreased sensitivity scan did not yield sufficiently strong results. Further, hardware associated with the methodology and programming optionally used to carry out the methods are part of the present invention.


Battelle Memorial Institute of Richland, Wash., has received US Patent No. 6,870,626, “Array-based photoacoustic spectroscopy.” The patent relates to methods and apparatus for simultaneous or sequential, rapid analysis of multiple samples by photoacoustic spectroscopy. A photoacoustic spectroscopy sample array including a body having at least three recesses or affinity masses connected thereto is used in conjunction with a photoacoustic spectroscopy system. At least one acoustic detector is positioned near the recesses or affinity masses for detection of acoustic waves emitted from species of interest within the recesses or affinity masses. In addition, photoacoustic spectroscopy sample arrays are disclosed. The sample arrays include a support having an array of affinity masses. The affinity masses comprise a material capable of retaining a sample having one or more analytes or capable of retaining the analyte itself, for PAS analysis. The affinity masses may comprise material having a specific affinity (chemical or physical) for the solution containing the one or more analytes of interest or for the analytes themselves. In one embodiment, the affinity masses may be formed on and/or connected to the sample array support. In another embodiment the sample array includes recesses formed in the support or formed in a substrate connected to the support. The recesses may retain affinity mass material for retaining analytes of interest. Alternatively, the recesses may simply retain solutions including one or more analytes of interest. Further, embodiments of the sample array may include at least one acoustic detector acoustically connected to or placed in the vicinity of the support to detect acoustic waves emitted by analytes of interest retained by the affinity masses of the sample array apparatus.

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