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High Throughput Genomics, NGK Insulators

High Throughput Genomics of Tucson, Ariz., has received US Patent No. 7,413,852, “Multiplexed diagnostic and therapeutics.” The patent claims a method and apparatus for analyzing molecular structures within a sample substance using an array, where the array has a plurality of test sites upon which the sample substance is applied. The patent also describes a method and apparatus for constructing molecular arrays having a plurality of test sites. The invention allows for definitive, high-throughput analysis of multiple analytes in complex mixtures of sample substances. A combinatorial analysis process is described that results in the creation of an array of integrated chemical devices. These devices operate in parallel, each unit providing specific sets of data that, when taken as a whole, give a complete answer for a defined experiment, the patent claims.

NGK Insulators of Nagoya, Japan, has received US Patent No. 7,414,117, “Nucleotide derivative and DNA microarray.” The patent describes a novel nucleotide derivative that may exist as a member of a single-stranded sequence and be bound to a DNA microarray. After undergoing a change in fluorescent signal intensity, depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is a thymin/uracil derivative, the nucleotide will emit light when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is a) adenine, a cytosine derivative; b) guanine, an adenine derivative; c) cytosine, a guanine derivative; d) cytosine or thymine/uracil, and an adenine derivative; or e) thymine/uracil.

The Scan

And Back

The New York Times reports that missing SARS-CoV-2 genome sequences are back in a different database.

Lacks Family Hires Attorney

A lawyer for the family of Henrietta Lacks plans to seek compensation from pharmaceutical companies that have used her cancer cells in product development, the Baltimore Sun reports.

For the Unknown

The Associated Press reports that family members are calling on the US military to use new DNA analysis techniques to identify unknown sailors and Marines who were on the USS Arizona.

PLOS Papers on Congenital Heart Disease, COVID-19 Infection Host MicroRNAs, Multiple Malformation Mutations

In PLOS this week: new genes linked to congenital heart disease, microRNAs with altered expression in COVID-19, and more.