Skip to main content
Premium Trial:

Request an Annual Quote

High Throughput Genomics, NGK Insulators

High Throughput Genomics of Tucson, Ariz., has received US Patent No. 7,413,852, “Multiplexed diagnostic and therapeutics.” The patent claims a method and apparatus for analyzing molecular structures within a sample substance using an array, where the array has a plurality of test sites upon which the sample substance is applied. The patent also describes a method and apparatus for constructing molecular arrays having a plurality of test sites. The invention allows for definitive, high-throughput analysis of multiple analytes in complex mixtures of sample substances. A combinatorial analysis process is described that results in the creation of an array of integrated chemical devices. These devices operate in parallel, each unit providing specific sets of data that, when taken as a whole, give a complete answer for a defined experiment, the patent claims.

NGK Insulators of Nagoya, Japan, has received US Patent No. 7,414,117, “Nucleotide derivative and DNA microarray.” The patent describes a novel nucleotide derivative that may exist as a member of a single-stranded sequence and be bound to a DNA microarray. After undergoing a change in fluorescent signal intensity, depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is a thymin/uracil derivative, the nucleotide will emit light when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is a) adenine, a cytosine derivative; b) guanine, an adenine derivative; c) cytosine, a guanine derivative; d) cytosine or thymine/uracil, and an adenine derivative; or e) thymine/uracil.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.