Harvard University of Cambridge, Mass., received US Patent No. 6,485,944, “Replica amplification of nucleic acid arrays.” The patent is for improved methods of making and using immobilized arrays of nucleic acids, particularly methods for producing replicas of such arrays. Included are methods for producing high-density arrays of nucleic acids and replicas of such arrays, as well as methods for preserving the resolution of arrays through rounds of replication.
Applera of Norwalk, Conn., received US Patent No. 6,485,939, “Isolated human transporter cofactor proteins, nucleic acid molecules encoding human transporter cofactor proteins, and uses thereof.” The patent covers a method that provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter cofactor peptides of the covered invention. The present invention specifically provides isolated peptide and nucleic acid molecules, as well as methods of identifying orthologs and paralogs of the transporter cofactor peptides, and methods of identifying modulators of the transporter cofactor peptides. It provides novel peptides and proteins that effect ligand transport and nucleic acid molecules encoding such peptide and protein molecules. The transporter cofactor proteins of the present invention are also useful to provide targets for diagnosing a disease.
Packard BioScience, now part of PerkinElmer of Boston, Mass., received US Patent No. 6,485,918 “Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate.” The patent is for a technology for incubating a liquid reagent with target spots on a microarray substrate. A deformable cover is placed over the surface of the microarray substrate having the target spots with the liquid reagent between the microarray substrate and the deformable cover, and a device is used to apply a force to the deformable cover.