Skip to main content
Premium Trial:

Request an Annual Quote

Harvard University, Applera, Packard BioScience


Harvard University of Cambridge, Mass., received US Patent No. 6,485,944, “Replica amplification of nucleic acid arrays.” The patent is for improved methods of making and using immobilized arrays of nucleic acids, particularly methods for producing replicas of such arrays. Included are methods for producing high-density arrays of nucleic acids and replicas of such arrays, as well as methods for preserving the resolution of arrays through rounds of replication.

Applera of Norwalk, Conn., received US Patent No. 6,485,939, “Isolated human transporter cofactor proteins, nucleic acid molecules encoding human transporter cofactor proteins, and uses thereof.” The patent covers a method that provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter cofactor peptides of the covered invention. The present invention specifically provides isolated peptide and nucleic acid molecules, as well as methods of identifying orthologs and paralogs of the transporter cofactor peptides, and methods of identifying modulators of the transporter cofactor peptides. It provides novel peptides and proteins that effect ligand transport and nucleic acid molecules encoding such peptide and protein molecules. The transporter cofactor proteins of the present invention are also useful to provide targets for diagnosing a disease.

Packard BioScience, now part of PerkinElmer of Boston, Mass., received US Patent No. 6,485,918 “Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate.” The patent is for a technology for incubating a liquid reagent with target spots on a microarray substrate. A deformable cover is placed over the surface of the microarray substrate having the target spots with the liquid reagent between the microarray substrate and the deformable cover, and a device is used to apply a force to the deformable cover.


The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.