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Goodgene, Palo Alto Research Center, Corning, Enzo Life Sciences, Industrial Technology Research Institute

Goodgene of Seoul, Korea, has received European Patent No. 1802756, “Probe of human papillomavirus and DNA chip comprising the same.” The patent describes probes that bind to the nucleic acid of the human papillomavirus that are attached to a microarray. A diagnosis kit is also claimed that enables users to analyze different genotypes of HPV and to detect the presence or absence of HPV infection in sample.

Palo Alto Research Center of Palo Alto, Calif., has received US Patent No. 7,241,420, “Capillary-channel probes for liquid pickup, transportation and dispense using stressy metal.” The patent claims fluidic conduits that can be used in microarraying systems, dip pen nanolithography systems, fluidic circuits, and microfluidic systems that use channel spring probes that include at least one capillary channel. According to the patent’s abstract, the channels are formed from spring beams that curve away from the substrate when released and can either be integrated into the spring beams or formed on the spring beams. Capillary forces produced by the narrow channels then allow liquid to be gathered, held, and dispensed by the channel spring probes. Because the channel spring beams can be produced using conventional semiconductor processes, significant design flexibility and cost efficiencies can be achieved, the patent’s abstract states.

Corning has received US Patent No. 7,241,629, “Detectable labels, methods of manufacture and use.” The patent claims labels, methods of making labels, and methods of using those labels for detecting the presence of an analyte in a sample and for detecting interactions of biomolecules. Specifically, the detectable label comprises a glass particle coated with rare earth elements, such as samarium or gadolinium, which are arranged in a pattern or array to provide a unique identification code that can identify a functional group, such as an antibody, protein, or nucleic acid, that is attached to the array.

Enzo Life Sciences has received US Patent No. 7,241,897, “Process for preparing cyanine dye labeling reagents.” The patent claims labeling reagents, labeled targets, and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes and are useful for labeling probes or targets, including nucleic acids and proteins, the patent’s abstract states. The reagents can also be usefully applied to protein and nucleic acid probe-based assays or to real-time detection processes.

Industrial Technology Research Institute, of Hsinchu, Taiwan, has received US Patent No. 7,242,472, “Biochip detection system.” The patent describes a system for detecting a biochip labeled with multiple fluorophores. The biochip detection system comprises: a) a broadband light source for generating a light beam; b) a stand for supporting the biochip; c) a light integrator positioned between the broadband light source and the biochip; d) a lens set for adjusting the cross-sectional area of the light beam; e) a first filter module positioned on the optical path of the light beam; f) a detector, such as a CCD camera; g) a photodiode array for detecting a fluorescence beam emitted from the biochip; and h) a second filter module positioned on the optical path of the fluorescence beam. The light integrator can be a light tunnel, a lens array or a holographic diffuser for making the intensity distribution of the light beam uniform and changing the cross-sectional shape of the light beam into a rectangle.

The Scan

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.

Study Presents New Insights Into How Cancer Cells Overcome Telomere Shortening

Researchers report in Nucleic Acids Research that ATRX-deficient cancer cells have increased activity of the alternative lengthening of telomeres pathway.

Researchers Link Telomere Length With Alzheimer's Disease

Within UK Biobank participants, longer leukocyte telomere length is associated with a reduced risk of dementia, according to a new study in PLOS One.

Nucleotide Base Detected on Near-Earth Asteroid

Among other intriguing compounds, researchers find the nucleotide uracil, a component of RNA sequences, in samples collected from the near-Earth asteroid Ryugu, as they report in Nature Communications.