GenoSpectra has received US Patent No. 6,594,432, “Microarray fabrication techniques and apparatus.” The patent covers a system and method for printing micro- arrays that has a printhead comprised of capillary bundles. These bundles can be random, and can provide a large number of probes on the surface. The patent also covers methods and equipment to detect defective microarrays that are missing probes.
Robert Bird, of Rockville, Md., has been awarded US Patent No. 6,593,084, “Carcinogen assay.” The patent refers to assays and methods to determine whether a specific agent is a carcinogen. These methods involve correlating differential gene expression patterns in mammalian cells treated with the agent to those treated with known carcinogens. The invention also specifies methods for using DNA and RNA isolated from these cells, and for determining whether an agent is a carcinogen by measuring protein synthesis or post-translational modifications of proteins in mammalian cells treated with the test agent, and comparing them to the post-translational modifications and protein synthesis in cells treated with known carcinogens.
Fuji Photo Film Co. has received US Patent No. 6,592,819, “Microarray chip manufacturing apparatus.” The patent covers an apparatus for manufacturing microarrays using picking pins to pick binding substances that are arranged either linearly or on two-dimensional patterns on a picking surface, and to spot these onto a chip with narrower dimensions than the original arrangements. The invention stipulates that the pins are movable, to enable changing of the spaces between them, as it moves from the picking surface to the chip.
Maven Technologies has received US Patent No. 6,594,011, “Imaging apparatus and method.” In the method, a light beam is passed through what is called a “total internal reflection” structure, and a genetic, other biological, or chemical sample is placed at the point of the total reflection for detection.