NEW YORK (GenomeWeb News) – In cancer cells, all sorts of functions go awry. In addition to genetic changes, many times there are also epigenetic changes.

DNA methylation typically regulates gene expression, but in cancer that, and other epigenetic controllers, don't act quite as they are supposed to. In many cancers, there is global hypomethylation of DNA, though there is also, paradoxically, hypermethylation at some CpG island promoters, especially in the promoters of tumor suppressor genes.

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In Genome Research this week, mismatch repair deficiency in C. elegans, retracing transcriptions start site evolution in the human genome, and more. 

May
01
Sponsored by
Horizon Discovery

This webinar will provide an in-depth case study demonstrating how reference standards can be used to develop and validate circulating tumor DNA (ctDNA)-based assays.

May
08
Sponsored by
Dovetail Genomics

This webinar will discuss a proximity ligation-based method for studying structural variation in formalin-fixed paraffin-embedded (FFPE) tissue.