NEW YORK (GenomeWeb News) – In cancer cells, all sorts of functions go awry. In addition to genetic changes, many times there are also epigenetic changes.

DNA methylation typically regulates gene expression, but in cancer that, and other epigenetic controllers, don't act quite as they are supposed to. In many cancers, there is global hypomethylation of DNA, though there is also, paradoxically, hypermethylation at some CpG island promoters, especially in the promoters of tumor suppressor genes.

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In Nature this week: Icelandic genome sequences, approach to increase CRISPR efficiency, and more.

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