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Genewave, Genedata

Genewave this week launched HybLive, an automated microarray platform that combines the functions of hybridization, washing, melting, and real-time fluorescence imaging in one system.
According to Genewave, the system also enables a variety of applications such as rapid verification and validation of probe design, environmental sample monitoring, multiplex on-chip melting curves determination, on-chip DNA and protein interaction studies.

Genedata this week released Expressionist 5.0, its enterprise high-throughput biomarker discovery platform.
According to Genedata, Expressionist 5.0 offers increased accuracy in classification analysis through the use of ROC curves, k-fold cross validation, and a host of other new tools; enhanced capabilities for cross-validation of expression data from different platforms or comparison of treatment effects in different samples; improved analysis of ontology relationships through a Gene Ontology browser; and support for Affymetrix GeneChip exon arrays.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.