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GeneData, Affymetrix, MWG-Biotech, Silicon Genetics, Alpha Innotech

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GeneData of Basel, Switzerland, has launched version 4.0 of its Expressionist suite for large-scale microarray processing. The package consists of three modules: Expressionist Refiner, Expressionist CoBi, and Expressionist Analyst. New features of version 4.0 include proprietary classification methods, multi-array processing capabilities, scripts to eliminate repetitive taks, and annotation for Affymetrix GeneChip layouts — including GenBank and Unigene accession numbers, LocusLink, MapLocation, GeneSymbol, Gene Ontology biological processes, cellular components, and molecular functions.

MWG-Biotech of Ebersberg, Germany, has released a 30K mouse gene expression microarray. The 30,000 mouse genes, covering the entire genome, are spread over three slides: The first slide, which has been on the market since December 2001, covers known genes with described functions. The second array mostly contains proven cDNA sequences but with limited functional information. The third slide covers sequences highly likely to be genes. According to the company, each oligo on the chip is based on a protein-coding region. In addition, MWG-Biotech offers mouse custom arrays based on the 30K array. Furthermore, a mouse 30K oligo set is available for customers who want to produce their own arrays. MWG’s Compact Gene Index for identifying relevant genes is also available for the 30K mouse array. Moreover, the company said it offers monthly introductory seminars on microarray technology.

Silicon Genetics of Redwood City, Calif., has updated its Enterprise Solution for expression informatics, releasing GeNet 3.0 and GeneSpring 5.0. New features include a sample-centric data storage paradigm, accelerated and simplified data loading, enterprise-wide querying tools, implementation of MIAME guidelines, automatic homology table generation allowing cross-species or cross-chip comparisons of gene expression data, 3D display tools, and a drag-and-drop user interface. By using distributed server and desktop computation, the system is able to serve a large number of users. It can also handle large sample volumes.

Alpha Innotech of San Leandro, Calif., has introduced FluorChem 8900, a new fluorescence imaging system. The instrument includes a patent-pending technology called Super-OD acquisition that allows it to acquire images up to an effective 18-bits of data and compress it into the standard 16-bit TIF file format. Details on the performance characteristics of Super-OD can be found in technology note No. 53, available at www.alphainnotech.com.

The Scan

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.