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GE Healthcare, Ciphergen Biosystems, Ribomed Biotechnologies

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GE Healthcare has received US Patent No. 7,047,141, "Ratio-based oligonucleotide probe selection." The patent claims a method of selecting a probe for a target nucleic acid sequence, comprising the steps of: a) hybridizing three or more candidate probes with a first composition that includes the target nucleic acid sequence; b) determining a first hybridization signal for each candidate probe; c) hybridizing the three or more candidate probes with a second composition that includes the target nucleic acid sequence; d) determining a second hybridization signal for each candidate probe; e) calculating a hybridization signal ratio of the first hybridization signal to the second hybridization signal for each candidate probe; f) calculating an average hybridization signal ratio for the three or more candidate probes; and g) selecting the candidate probe by comparing a candidate probe's hybridization signal ratio to the average hybridization signal ratio.


Ciphergen Biosystems has received US Patent No. 7,045,366, "Photocrosslinked hydrogel blend surface coatings." The patent claims hydrogel polymer blends including precursors and crosslinked forms of the compositions that can be used in mass spectral analysis of biomolecular analytes such as proteins, as well as a low- or high-density microarray of enzyme-containing gel pads.


Ribomed Biotechnologies of Phoenix, Ariz., has received US Patent No. 7,045,319, "Molecular detection systems utilizing reiterative oligonucleotide synthesis." The patent claims methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through enzymatic oligonucleotide synthesis events on a polynucleotide sequence. The methods generally comprise: a) using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide to initiate synthesis of an oligonucleotide product that is complementary to a target site on the defined polynucleotide sequence; b) optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators; c) using a chain terminator to terminate the polymerization reaction; and d) detecting multiple oligonucleotide products that have been synthesized by the polymerase. The patent also describes a method for producing a microarray by synthesizing multiple abortive oligonucleotide replicates from a target DNA sequence and attaching the multiple abortive oligonucleotide replicates to a solid substrate to produce a microarray of the replicates.

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