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Funding Update: NSF Microarray Grants: Sep 24, 2013


NSF Microarray Grants Awarded June 25 — Sept. 24, 2013

Localized surface plasmon resonance (LSPR) biosensing microarray for multiplex, real-time single-cell immunophenotyping
Start Date: Aug. 1, 2013
Expires: July 31, 2016
Awarded amount to date: $330,000
Principal investigator: Katsuo Kurabayashi
Sponsor: University of Michigan – Ann Arbor

This research aims to establish a biosensing platform that enables high-throughput, multiplexed, dynamic measurement of cytokines secreted by target immune cells isolated from whole blood at the single-cell level. This single-cell functional assay efficiently permits on-chip isolation and stimulation of single cells and detection of cell-secreted proteins. The investigators' approach will use localized surface plasmon resonance imaging within microchamber arrays, each capturing a single cell. As a result of miniaturization of the whole system, both the sample volume and the total assay time can be reduced.

Molecular simulation of DNA interactions in oligonucleotide microarrays
Start Date: Aug. 1, 2013
Expires: July 31, 2016
Awarded amount to date: $150,000
Principal investigator: John Stubbs
Sponsor: University of New England

The aspects of this project explore the differences between surface- and solution-based transitions for systems that are most pertinent to DNA microarray technology. The hybridization and denaturation transitions between single- and doubled-stranded DNA will be studied for short oligomers, between 10 and 25 bases, both in solution and with one strand bound to a surface to determine how surface immobilization affects this equilibrium and the interactions between strands.

Electrochemical microarray on monolith electrode: exploratory research
Start Date: Sept. 1, 2013
Expires: Aug. 31, 2014
Awarded amount to date: $90,309
Principal investigator: Ravi Saraf
Sponsor: University of Nebraska – Lincoln

The investigators are developing an electrochemical method for profiling miRNA by measuring local redox reactions on a monolith electrode by scanning a laser beam over various microarray binding sites. The electrochemical signal can potentially distinguish a perfect match between an immobilized probe and a target binding, and no redox occurs on nonspecific binding, they claim in the grant abstract.

Statistical methods for integrated analysis of high-throughput biomedical data
Start Date: Sept. 15, 2013
Expires: Aug. 31, 2017
Awarded amount to date: $317,967
Principal investigator: Pradeep Ravikumar, Genevera Allen, Zhandong Liu
Sponsors: University of Texas at Austin, Rice University, Baylor College of Medicine

The investigators will develop a new statistical framework for integrated analysis of multiple sets of high-dimensional data measured on the same group of subjects. This research will be applied to high-throughput cancer genomics data, including array data, and lead to new methods to discover molecular cancer sub-types along with their genomic signatures and build a holistic network model of disease.

The Scan

Foxtail Millet Pangenome, Graph-Based Reference Genome

Researchers in Nature Genetics described their generation of a foxtail millet pangenome, which they say can help in crop trait improvement.

Protein Length Distribution Consistent Across Species

An analysis in Genome Biology compares the lengths of proteins across more than 2,300 species, finding similar length distributions.

Novel Genetic Loci Linked to Insulin Resistance in New Study

A team reports in Nature Genetics that it used glucose challenge test data to home in on candidate genes involved in GLUT4 expression or trafficking.

RNA Editing in Octopuses Seems to Help Acclimation to Shifts in Water Temperature

A paper in Cell reports that octopuses use RNA editing to help them adjust to different water temperatures.