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Funding Update: NIH Microarray Grants

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Microarray-Related NIH Grants, March 21, 2013 – July 16, 2013

Planar Polarity Mechanisms in Mammalian Inner Ear Development
Principal investigator: Michael Deans
Organization: Johns Hopkins University
Project start date: March 25, 2013
Project end date: Feb. 28, 2018
NIH institute: NIDCD
FY 2013 funding amount: $344,250


Statistical Analysis of Epigenomics Data
Principal investigator: Kimberly Siegmund
Organization: University of Southern California
Project start date: March 26, 2013
Project end date: Feb. 29, 2016
NIH institute: NHGRI
FY 2013 funding amount: $365,544


MicroRNAs: A New Mechanism Negatively Regulating B Cell Responses in the Elderly
Principal investigator: Daniela Frasca
Organization: University of Miami School of Medicine
Project start date: April 1, 2013
Project end date: March 31, 2015
NIH institute: NIA
FY 2013 funding amount: $191,771


Optimizing Anti-Virulence Compounds for the Treatment of UTIs
Principal investigator: Sarah Greene
Organization: Washington University
Project start date: April 1, 2013
Project end date: March 31, 2014
NIH institute: NIDDKD
FY 2013 funding amount: $28,498


Genome-Wide Exploration of DNA Methylation Markers for Thyroid Cancer
Principal investigator: Michael Xing
Organization: Johns Hopkins University
Project start date: April 1, 2013
Project end date: March 31, 2015
NIH institute: NCI
FY 2013 funding amount: $211,410


Lung Adenocarcinoma Invasion Genomics
Principal investigator: Charles Powell
Organization: Mount Sinai School of Medicine
Project start date: April 1, 2013
Project end date: March 31, 2018
NIH institute: NCI
FY 2013 funding amount: $603,855


Functional Analysis of Manic Fringe in the Claudin-Low Breast Cancer
Principal investigator: Keli Xu
Organization: University of Mississippi Medical Center
Project start date: April 1, 2013
Project end date: March 31, 2015
NIH institute: NCI
FY 2013 funding amount: $170,226


Isolation and Characterization of Tumor Stem Cells from Melanoma Patients
Principal investigator: Alexander Boiko
Organization: University of California, Irvine
Project start date: April 1, 2013
Project end date: March 31, 2016
NIH institute: NCI
FY 2013 funding amount: $112,052


Real-Time Internal Calibration for Multiplexed Microarray Analysis
Principal investigator: Marc Porter
Organization: University of Utah
Project start date: April 1, 2013
Project end date: March 31, 2015
NIH institute: NIBIB
FY 2013 funding amount: $223,688


Epigenetic Regulation of Breast Cancer Progression by the Proto-Oncogene PELP1
Principal investigator: Monica Mann
Organization: University of Texas Health Sciences Center, San Antonio
Project start date: April 1, 2013
Project end date: Not specified.
NIH institute: NCI
FY 2013 funding amount: $28,876


Perturbations of Host Cell Signaling by a Complex Hepatotropic Pathogen
Principal investigator: Stefan Kappe
Organization: Seattle Biomedical Research Institute
Project start date: April 1, 2013
Project end date: March 31, 2017
NIH institute: NIGMS
FY 2013 funding amount: $352,201


Validation of Biomarkers to Distinguish Aggressive from Indolent Prostate Cancer
Principal investigator: George Wilding
Organization: University of Wisconsin, Madison
Project start date: April 1, 2013
Project end date: March 31, 2015
NIH institute: NCI
FY 2013 funding amount: $208,940


Microparticle Capture-Based Analysis of Lymph Node Proteome
Principal investigator: Serguei Popov
Organization: George Mason University
Project start date: April 15, 2013
Project end date: March 31, 2015
NIH institute: NIAID
FY 2013 funding amount: $184,063


Role of Maternal Diet and Allelic Imbalance in Behavior
Principal investigator: Lisa Tarantino
Organization: University of North Carolina, Chapel Hill
Project start date: April 19, 2013
Project end date: March 31, 2018
NIH institute: NIMH
FY 2013 funding amount: $602,068


Optimization of IsoRaft Technology for Stem Cell Market
Principal investigator: Yuli Wang
Organization: Cell Microsystems
Project start date: May 1, 2013
Project end date: Nov. 30, 2013
NIH institute: NIGMS
FY 2013 funding amount: $151,352


Regulation of Hepatic Substrate Flux by Leptin via POMC Neurons and Hepatocytes
Principal investigator: Eric Berglund
Organization: University of Texas Southwestern Medical Center
Project start date: May 1, 2013
Project end date: March 31, 2016
NIH institute: NIDDK
FY 2013 funding amount: $101,844


Cockayne Syndrome: Role of the Innate Immune Response in Neurodegeneration
Principal investigator: Alan Weiner
Organization: University of Washington
Project start date: May 1, 2013
Project end date: April 30, 2015
NIH institute: NINDS
FY 2013 funding amount: $270,375


C-Abl-Mediated Suppression of Breast Cancer Development and Metastasis
Principal investigator: William Schiemann
Organization: Case Western Reserve University
Project start date: May 14, 2013
Project end date: March 31, 2018
NIH institute: NCI
FY 2013 funding amount: $342,360


Localizing Maternal and Fetal Message in Translation of Preeclampsia Candidate Genes
Principal investigator: Sandra Founds
Organization: University of Pittsburgh
Project start date: May 15, 2013
Project end date: March 31, 2015
NIH institute: NINR
FY 2013 funding amount: $76,250


Electrochemically-Enhanced Plasmonic Imaging for Quantitative Proteomics
Principal investigator: Nguyen Ly
Organization: Biosensing Instrument
Project start date: May 15, 2013
Project end date: March 31, 2015
NIH institute: NIGMS
FY 2013 funding amount: $350,000


Decellularized Stem Cell Matrix Rejuvenates Human Cells from Herniated Discs
Principal investigator: Ming Pei
Organization: West Virginia University
Project start date: June 1, 2013
Project end date: May 31, 2016
NIH institute: NIAMSD
FY 2013 funding amount: $74,000


Life Course Cancer Epidemiology Cohort in Women
Principal investigator: Walter Willett
Organization: Harvard University
Project start date: June 1, 2013
Project end date: May 31, 2018
NIH institute: NCI
FY 2013 funding amount: $2,667,092


ISG15 Responsive Pathway
Principal investigator: Dusan Bogunovic
Organization: Rockefeller University
Project start date: June 1, 2013
Project end date: May 31, 2014
NIH institute: NIAID
FY 2013 funding amount: $106,206


Instrumentation Enabling a 16-Fold Decrease in Oligonucleotide Cost
Principal investigator: Keith Anderson
Organization: Synthomics
Project start date: June 1, 2013
Project end date: Nov. 30, 2013
NIH institute: NHGRI
FY 2013 funding amount: $135,100


Biospecimen Preparation Technologies
Principal investigator: James Lai
Organization: University of Washington
Project start date: June 1, 2013
Project end date: May 31, 2016
NIH institute: NCI
FY 2013 funding amount: $210,786


The PKC Epsilon-Regulated Oncogenic and Tumor Suppressor Roles of ATF2 in Melanoma
Principal investigator: Erik Lau
Organization: Sanford-Burnham Medical Research Institute
Project start date: July 1, 2013
Project end date: June 30, 2015
NIH institute: NCI
FY 2013 funding amount: $107,838


Deoxyribozome Sensor-Based Diagnostics for Mycobacterium Tuberculosis
Principal investigator: Dmitriy Kolpashchikov
Organization: University of Central Florida
Project start date: July 1, 2013
Project end date: June 30, 2016
NIH institute: NIAID
FY 2013 funding amount: $429,965


Metformin as a Novel Chemopreventive Agent for Prostate Cancer
Principal investigator: Xin Li
Organization: New York University
Project start date: July 1, 2013
Project end date: June 30, 2015
NIH institute: NCI
FY 2013 funding amount: $78,709


Fluidigm BioMark HD MX/HX Real-Time PCR System
Principal investigator: Shirley Luckhart
Organization: University of California, Davis
Project start date: July 1, 2013
Project end date: June 30, 2014
NIH institute: OID
FY 2013 funding amount: $261,191


Pharmacodynamics of Biased G Protein-Coupled Receptor Agonism
Principal investigator: Louis Luttrell
Organization: Medical University of South Carolina
Project start date: July 1, 2013
Project end date: June 30, 2017
NIH institute: NIGMS
FY 2013 funding amount: $284,050


Regulation of Orofacial Ectodermal Polarity by the CLP Protein, IRF6
Principal investigator: Emily Chu
Organization: University of Washington
Project start date: July 1, 2013
Project end date: June 30, 2014
NIH institute: NIDCR
FY 2013 funding amount: $36,607


Molecular Definition of Brain Circuits Controlling Addiction
Principal investigator: Nathaniel Heintz
Organization: Rockefeller University
Project start date: July 1, 2013
Project end date: Feb. 28, 2018
NIH institute: NIDA
FY 2013 funding amount: $1,376,766


A Novel Strategy to Identify Prostate Cancer Biomarkers for Patient Management
Principal investigator: Jiaoti Huang
Organization: University of California, Los Angeles
Project start date: July 1, 2013
Project end date: May 31, 2018
NIH institute: NCI
FY 2013 funding amount: $319,550


Targeting C-Myc and MDR1 in Cancer through Small Molecule Inhibitors of IMP-1
Principal investigator: David Shapiro
Organization: University of Illinois, Urbana-Champaign
Project start date: July 1, 2013
Project end date: June 30, 2015
NIH institute: NCI
FY 2013 funding amount: $199,598


SMRT-2 in Epidermal Neoplasia
Principal investigator: Aparna Bhaduri
Organization: Stanford University
Project start date: July 1, 2013
Project end date: June 30, 2015
NIH institute: NCI
FY 2013 funding amount: $42,232


Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
Principal investigator: Vikram Ramkumar
Organization: Southern Illinois University School of Medicine
Project start date: July 1, 2013
Project end date: June 30, 2018
NIH institute: NCI
FY 2013 funding amount: $299,430


Molecular Targets Phase III Core
Principal investigator: Donald Miller
Organization: University of Louisville
Project start date: July 1, 2013
Project end date: June 30, 2018
NIH institute: NIGMS
FY 2013 funding amount: $1,121,000


Interaction of Colonizer and Pathogen in Oral Biofilm
Principal investigator: Ping Xu
Organization: Virginia Commonwealth University
Project start date: July 5, 2013
Project end date: May 31, 2018
NIH institute: NIDCR
FY 2013 funding amount: $381,250

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.