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Fuji Photo Film, SurModics, Francis Barany, Affymetrix

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Fuji Photo Film of Kanagawa-ken, Japan, has received US Patent No. 6,507,426, “Scanner apparatus.” The patent covers a fluorescent scanner that performs bidirectional scanning on a microarray chip by using an integration amplifying detector, which is capable of preventing the occurrence of jitters, according to the abstract information on the patent.

SurModics of Eden Prairie, Minn., received US Patent No. 6,506,895, “Photoactivatable nucleic acids.” The patent covers a photoactivatable nucleic acid where photoreactive groups are bound to a natural or synthetic nucleic acid and attached to another molecule, for instance, the surface of a solid support. The patent also includes a method of preparing the substance, and a method of attaching the nucleic acid to another molecule, such as that provided by the surface of a substrate used to prepare a nucleic acid chip by photolithographic techniques.

Francis Barany of New York received US Patent No. 6,506,594, “Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays.” The patent covers a method for identifying one or more sequences differing by one or more single base changes in target nucleotide sequences. The ligation phase utilizes a reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridization to a solid support with an array of immobilized capture oligos complementary to the addressable array-specific portion.

Affymetrix received US Patent No. 6,510,391, “Computer software products for nucleic acid hybridization analysis.” The patent covers a system and technology for analyzing gene expression data that employs multiple probes against a single target. The hybridization intensities of each probe is adjusted by dividing the intensity by the affinities of the probes. The minimal adjusted hybridization intensity may be used as the measurement of the gene expression.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.