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Fuji Photo Film, Quantum Dot, High Throughout Genomics, Jewish General Hospital in Montreal, Genetix, Nanosphere


Fuji Photo Film of Kanagawa-ken, Japan, received US Patent No. 6,759,673, “Radiation image readout method and apparatus.” The patent covers an apparatus to record at high resolution and sensitivity the radiation produced by a phosphor sheet. The technology can be applied to the imaging of microarrays.

Quantum Dot received US Patent No. 6,759,235, “Two-dimensional spectral imaging system.” The patent covers a technology for sensing and identifying signals from within a signal detection region through the use of spectral codes that can be generated by quite small bodies. Signals can be read by a CCD camera to identify the relative wavelengths of signals making up the spectra.

High Throughout Genomics of Tucson, Ariz., received US Patent No. 6,759,198, “High throughput assay system.” The patent covers a technology for performing multiple, high-throughput, biological or chemical assays, using repeated arrays of probes. It is composed of a surface containing test regions with arrays of generic anchor molecules. The anchors are associated with bifunctional linker molecules, each containing a portion that is specific for at least one of the anchors and a portion that is a probe specific for a target of interest. The resulting array of probes is used to analyze the presence or test the activity of one or more target molecules that specifically interact with the probes.

The Jewish General Hospital in Montreal received US Patent No. 6,759,197, “Microchip arrays of regulatory genes.” The patent covers a method for utilizing genes of the same regulatory modality for microarray analysis. The transcriptional regulation of these genes is related to the same control element, the E-box, defined by the sequence CACGTG. PCR products of selected regions of all known genes either binding to this sequence or whose expression is dependent on this binding, as well as genes interacting with E-box-binding genes and control genes, are arrayed on a nylon membrane or other appropriate microchip susbstrate, which is then used as an E-box-specific microarray. The transcriptionally regulated profile of E-box-related genes specific to a given cultured cell sample is then determined by unique labeled cDNAs probes produced from RNAs isolated from the culture of interest.

Genetix received US Patent No. 6,759,012, “Pin holder for a microarraying apparatus.” The patent covers a technology for holding the pins used in the robots that spot microarrays.

Nanosphere received US Patent No. 6,759,199, “Nanoparticles having oligonucleotides attached thereto and uses therefore.” The patent is one in a series that have been issued covering the company’s technology for detecting nucleic acids.


The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.