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Expression Diagnostics, BioMicro Systems

Expression Diagnostics of South San Francisco, Calif., has received US Patent No. 7,235,358, “Methods and compositions for diagnosing and monitoring transplant rejection.” The patent describes methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient. According to the patent’s abstract, the gene expression system used for diagnosis may be a candidate library, a diagnostic agent, a diagnostic oligonucleotide set or a diagnostic probe set. The gene expression system may also be immobilized on an array, such as a chip array, a plate array, a bead array, a pin array, a membrane array, a solid surface array, a liquid array, an oligonucleotide array, a polynucleotide array, a cDNA array, or a microfilter plate.

BioMicro Systems of Salt Lake City has received US Patent No. 7,235,400, “Laminated microarray interface device.” The patent claims a device for forming a low-volume reaction chamber on a substrate such as a microarray slide as well as its method of use. According to the patent, the reaction chamber forming device has an adhesive laminate design that permits it to be manufactured as a disposable device. The patent also describes pneumatically actuatable mixing bladders, which can be inflated or deflated to produce deflection of a wall of the reaction chamber in and out with respect to the reaction chamber to generate movement and mixing of fluid within the reaction chamber in, for example, a hybridization station.

The Scan

Support for Moderna Booster

An FDA advisory committee supports authorizing a booster for Moderna's SARS-CoV-2 vaccine, CNN reports.

Testing at UK Lab Suspended

SARS-CoV-2 testing at a UK lab has been suspended following a number of false negative results.

J&J CSO to Step Down

The Wall Street Journal reports that Paul Stoffels will be stepping down as chief scientific officer at Johnson & Johnson by the end of the year.

Science Papers Present Proteo-Genomic Map of Human Health, Brain Tumor Target, Tool to Infer CNVs

In Science this week: gene-protein-disease map, epigenomic and transcriptomic approach highlights potential therapeutic target for gliomas, and more