Skip to main content
Premium Trial:

Request an Annual Quote

Expression Diagnostics, BioMicro Systems

Expression Diagnostics of South San Francisco, Calif., has received US Patent No. 7,235,358, “Methods and compositions for diagnosing and monitoring transplant rejection.” The patent describes methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient. According to the patent’s abstract, the gene expression system used for diagnosis may be a candidate library, a diagnostic agent, a diagnostic oligonucleotide set or a diagnostic probe set. The gene expression system may also be immobilized on an array, such as a chip array, a plate array, a bead array, a pin array, a membrane array, a solid surface array, a liquid array, an oligonucleotide array, a polynucleotide array, a cDNA array, or a microfilter plate.

BioMicro Systems of Salt Lake City has received US Patent No. 7,235,400, “Laminated microarray interface device.” The patent claims a device for forming a low-volume reaction chamber on a substrate such as a microarray slide as well as its method of use. According to the patent, the reaction chamber forming device has an adhesive laminate design that permits it to be manufactured as a disposable device. The patent also describes pneumatically actuatable mixing bladders, which can be inflated or deflated to produce deflection of a wall of the reaction chamber in and out with respect to the reaction chamber to generate movement and mixing of fluid within the reaction chamber in, for example, a hybridization station.

The Scan

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.

Clinical Genomic Lab Survey Looks at Workforce Needs

Investigators use a survey approach in Genetics in Medicine Open to assess technologist applications, retention, and workforce gaps at molecular genetics and clinical cytogenetics labs in the US.

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

Investigators in Genome Biology set sequence-based models against observational and perturbation assay data, finding distal enhancer models lag behind promoter predictions.

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.