NEW YORK (GenomeWeb News) - A group of three European academic research institutes will use Affymetrix technology in an initiative aimed at identifying mutations in mentally retarded children, the company said today.
The European Cytogenetic Research Initiative includes Affymetrix, the University of Tuebingen in Germany, the NHS Regional Genetics Laboratory in the UK, and the University of Nijmegen in the Netherlands, Affy said.
The three institutions will use Affy's microarrays to provide a high-resolution look at the human genome, "enabling researchers to better identify causative mutations, copy number variants, and loss of heterozygosity information," the company said.
University of Tuebingen's Olaf Riess said that by using the Affy microarrays, the collaborators "expect to find a much higher number of causal de novo deletions and amplifications than we could with the current gold-standard methods like karyotyping."
"Each year up to 30,000 children with learning difficulties will be tested in the UK alone using karyotyping and targeted FISH methods," said NHS' head of molecular cytogenetics, Dominic McMullan. But "these technologies are only helping to resolve five to ten percent of cases," McMullan added.