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Eppendorf Array Technology, Samsung, Canon, Affymetrix, Jivan Biologics

Eppendorf Array Technology of Namur, Belgium, has received US Patent No. 7,338,763, “Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays.” The patent claims a method and a kit for the specific identification and quantification of organisms in a biological sample that is possibly contaminated by other organisms. The method allows the detection at least one nucleotide sequence specific of each of the organisms present in the biological sample by: a) amplifying the sequences; b) contacting the target amplified sequences with the array in a solution under conditions allowing hybridization of the target amplified sequences to complementary capture nucleotide sequences present on the array; and c) detecting and quantifying signals present on specific locations on the array, where the intensities of the signals in specific locations allow identification of the organisms.

Samsung of Seoul, Korea, has received US Patent No. 7,338,764, “Polynucleotide microarray including two or more groups of probe polynucleotides immobilized on substrate according to melting temperature and method for detecting target polynucleotides using the same.” The patent claims a method for detecting target polynucleotides by spotting samples containing target polynucleotides onto probe polynucleotides immobilized on a polynucleotide microarray. According to the patent, the polynucleotide microarray includes two or more groups of spots on which probe polynucleotides are immobilized. The probe polynucleotides are grouped according to a melting temperature in a first hybridization solution between the probe polynucleotides and target polynucleotides. Each group of spots or the samples is then contacted with a second hybridization solution, where the second hybridization solution for a group of spots comprises a denaturant, a stabilizer, or a mixture of the two. The target polynucleotides are then hybridized to the probe polynucleotides immobilized on each group of spots at the hybridization temperature and a result of the hybridization to detect the target polynucleotides is detected.

Canon of Tokyo has received US Patent No. 7,338,810, “Substrate processing method and method for manufacturing probe carrier.” The patent claims a method for processing a non-porous substrate, where the substrate contains a surface on which probes capable of specifically binding a target substance are immobilized. The method includes the steps of: a) supplying a liquid including the probes onto the surface of the non-porous substrate to immobilize the probes on the substrate; b) setting a sheet of a material to form a space between the substrate and the material for accommodating the probes; c) injecting a solution into the space; d) freezing the non-porous substrate together with the solution; and e) placing the non-porous substrate under a reduced pressure to sublimate solvent components in the solution frozen in the freezing step, where the substrate is cleaned after supplying the liquid, but before setting the sheet of the material.

Affymetrix has received US Patent No. 7,339,049, “Polymorphisms in human mitochondrial DNA.” The patent describes human mitochondrial polymorphisms, and probes and primers for detecting them. Detection of the polymorphisms is useful in a variety of fields including forensic analysis, epidemiology, and preventive medicine, the patent’s abstract states.

Jivan Biologics of Larkspur, Calif., has received US Patent No. 7,340,349, “Method and system for identifying splice variants of a gene.” The patent claims a computer-implemented method for identifying expression levels of multiple expected polynucleotide splice variants of a gene in a sample. The method works by: a) obtaining expression level data from a microarray experiment for indicator polynucleotides specific to exon-exon junctions of multiple expected splice variants of a gene; and b) applying a computer-implemented mathematical algorithm to the expression level data for the polynucleotides to identify expression levels of each expected polynucleotide splice variant in the sample.

The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.