Duke Team Assesses Functionality of Common, Rare Variants | GenomeWeb

The less common a gene variant is, the more likely it is to be functional, according to new research out of David Goldstein's lab at Duke University. This finding would contradict the common disease, common variant hypothesis that underpins many genome-wide association studies and instead lends credence to the idea that rare variants are behind common diseases, a theory that Goldstein has long suggested.

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