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Corning, Hai Kang Life, Applera

Corning of Corning, NY, has received US Patent No. 7,390,463, “Microcolumn-based, high-throughput microfluidic device.” The patent claims a biological assay device for use in molecular biology, pharmaceutical research, genomic analysis, combinatorial chemistry, and in the general field of the analysis of molecules. Specifically, the device includes a fluidic or microfluidic device, which integrates fluidic capability into existing multi-well plates of standard configuration, for performing either single or continuous fluidic manipulations in a high-throughout format. Methods for the use and manufacture of these devices are also provided.

Hai Kang Life of Hong Kong has received US Patent No. 7,390,622, “Apparatus and methods for detecting nucleic acid in biological samples.” The patent claims a method of performing field-assisted hybridization in the detection of nucleic acid targets from a sample by: a) providing a reaction cell having a layer formed of a dielectric material defining an attachment surface; b) providing a metal electrode in direct contact with the dielectric attachment layer; c) attaching nucleic acid capture probes to the dielectric attachment layer; d) adding the sample to the reaction cell; and e) providing an electrical potential to the metal electrode causing a charge separation in the dielectric attachment layer but without generating a flow of electric current or causing transfer of electrons between the layer and the sample.

Applera has received US Patent No. 7,388,664, “Methods for improving the performance of a detector.” The patent claims a system and method for allowing adjustments of various parameters associated with the operation of charge-coupled devices adapted for use in biological analysis devices, such as probe arrays. Gate voltage signals applied to the CCDs can be adjusted to affect the manner in which charge is transferred from pixels. The manner in which transferred charges from the pixels are processed in a readout process can also be adjusted to advantageously change the speed of the CCD based detector. Various methods of performing such adjustments are disclosed.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.