Copy Machines

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To hear Charles Lee, a Harvard Medical School cytogeneticist, tell it, he and his colleagues came upon the notion of copy-number variants more or less by accident.

Not that researchers hadn't previously noticed these genetic elements — roughly defined as DNA segments occurring in different numbers across different genomes. In the early 1990s, for instance, Baylor College of Medicine professor James Lupski explored the role of CNVs in Charcot-Marie-Tooth neuropathy, identifying duplications linked to the most common form of the disorder.

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In PLOS this week: comparison of commercial bisulfite kits, new method to predict essential proteins, and more

Jun
21
Sponsored by
Roche

This webinar will provide a detailed look at how a genomics lab implemented next-generation sequencing (NGS) liquid biopsy assays into its in-house clinical research program.